PMID: 9445063Jan 28, 1998Paper

CD4+-T-cell and CD20+-B-cell changes predict rapid disease progression after simian-human immunodeficiency virus infection in macaques

Journal of Virology
K K StegerC David Pauza

Abstract

Simian-human immunodeficiency virus 89.6PD (SHIV89.6PD) was pathogenic after intrarectal inoculation of rhesus macaques. Infection was achieved with a minimum of 2,500 tissue culture infectious doses of cell-free virus stock, and there was no evidence for transient viremia in animals receiving subinfectious doses by the intrarectal route. Some animals experienced rapid progression of disease characterized by loss of greater than 90% of circulating CD4+ T cells, sustained decreases in CD20+ B cells, failure to elicit virus-binding antibodies in plasma, and high levels of antigenemia. Slower-progressing animals had moderate but varying losses of CD4+ T cells; showed increases in circulating CD20+ B cells; mounted vigorous responses to antibodies in plasma, including neutralizing antibodies; and had low or undetectable levels of antigenemia. Rapid progression led to death within 30 weeks after intrarectal inoculation. Plasma antigenemia at 2 weeks after inoculation (P < or = 0.002), B- and T-cell losses (P < or = 0.013), and failure to seroconvert (P < or = 0.005) were correlated statistically with rapid progression. Correlations were evident by 2 to 4 weeks after intrarectal SHIV inoculation, indicating that early events in the h...Continue Reading

References

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Citations

Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·R C Gallo
Jan 27, 2005·Viral Immunology·Paul M WatermanC David Pauza
Jun 5, 1999·AIDS Research and Human Retroviruses·D C Montefiori, T G Evans
Jun 20, 2014·Alcoholism, Clinical and Experimental Research·Robert W SigginsDavid A Welsh
Oct 29, 2000·Neuropathology and Applied Neurobiology·M K LuabeyaR L Hamilton
Apr 9, 2005·Cell Death and Differentiation·B HurtrelJ Estaquier
Mar 5, 2008·Clinical & Developmental Immunology·Maria S SalvatoC David Pauza
Nov 13, 1999·Journal of Virology·J M CrawfordD C Montefiori
Aug 28, 2004·The American Journal of Pathology·Raghava PotulaShilpa Buch

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