CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell Proliferation

The Journal of Immunology : Official Journal of the American Association of Immunologists
K AyasoufiA Valujskikh

Abstract

Ab-mediated lymphoablation is commonly used in solid organ and hematopoietic cell transplantation. However, these strategies fail to control pathogenic memory T cells efficiently and to improve long-term transplant outcomes significantly. Understanding the mechanisms of T cell reconstitution is critical for enhancing the efficacy of Ab-mediated depletion in sensitized recipients. Using a murine analog of anti-thymocyte globulin (mATG) in a mouse model of cardiac transplantation, we previously showed that peritransplant lymphocyte depletion induces rapid memory T cell proliferation and only modestly prolongs allograft survival. We now report that T cell repertoire following depletion is dominated by memory CD4 T cells. Additional depletion of these residual CD4 T cells severely impairs the recovery of memory CD8 T cells after mATG treatment. The CD4 T cell help during CD8 T cell recovery depends on the presence of B cells expressing CD40 and intact CD40/CD154 interactions. The requirement for CD4 T cell help is not limited to the use of mATG in heart allograft recipients, and it is observed in nontransplanted mice and after CD8 T cell depletion with mAb instead of mATG. Most importantly, limiting helper signals increases the eff...Continue Reading

References

May 1, 1995·The Journal of Clinical Investigation·M RoedererL A Herzenberg
May 16, 1998·The Journal of Experimental Medicine·M GonzalezR J Noelle
Jun 8, 1999·Annual Review of Immunology·Y X Fu, D D Chaplin
Mar 23, 2001·Nature Immunology·K S SchlunsL Lefrançois
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·J T TanC D Surh
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M PrlicS C Jameson
Dec 26, 2001·The Journal of Experimental Medicine·V N NgoJ G Cyster
Sep 21, 2002·Science·Christine BourgeoisCorinne Tanchot
Apr 12, 2003·Science·Joseph C Sun, Michael J Bevan
Dec 3, 2003·Nature Medicine·Zihao WuLaurence A Turka
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yifa ChenAnna Valujskikh
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qian GongAndrew C Chan
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jonathan P PearlAllan D Kirk
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·William C KieperCharles D Surh
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Booki MinWilliam E Paul
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosa M AndradeCarlos S Subauste
Nov 19, 2005·The Journal of Clinical Investigation·Shiqian ShenJuan J Lafaille
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiwei ZhangAnna Valujskikh
Mar 23, 2006·Annual Review of Immunology·Flora Castellino, Ronald N Germain
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·David C NeujahrLaurence A Turka
Feb 7, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A ZeeviK R McCurry
Feb 9, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I KoyamaT Kawai
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anupama AhujaMark J Shlomchik
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q-W ZhangA Valujskikh
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colleen J WinsteadAlexander Khoruts
Jul 19, 2008·The New England Journal of Medicine·Ashley A VoStanley C Jordan
Nov 5, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas HaudebourgBernard Vanhove
Dec 23, 2008·Immunity·Charles D Surh, Jonathan Sprent
Jun 19, 2009·The New England Journal of Medicine·Menna R ClatworthyKenneth G C Smith
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y-H NgG Chalasani
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S GurkanB Murphy
Sep 17, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I R BadellC P Larsen
Mar 17, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N K Tchao, L A Turka
Aug 1, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M LoweK A Reimann
Jan 22, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K AyasoufiA Valujskikh
Jul 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S IidaR Abe

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Citations

Apr 12, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K AyasoufiA Valujskikh
Nov 27, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Nicosia, A Valujskikh
Dec 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Katayoun AyasoufiAnna Valujskikh
Dec 7, 2019·Immunological Reviews·Christina R HartiganMandy L Ford
Jan 28, 2020·Immunopharmacology and Immunotoxicology·Anantha Maharasi RamakrishnanKavitha Sankaranarayanan
Apr 29, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Suheyla HasgurAnna Valujskikh
Jul 8, 2020·The Journal of Clinical Investigation·Ainhoa Perez-DiezIrini Sereti
Feb 11, 2020·Transplantation·Michael NicosiaAnna Valujskikh
Mar 16, 2017·Frontiers in Immunology·Gilles BenichouAnna Valujskikh
May 5, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·He XuAllan D Kirk

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