CD4+ T cell-independent maintenance and expansion of memory CD8+ T cells derived from in vitro dendritic cell activation

International Immunology
Meiqing Shi, Jim Xiang

Abstract

CD4+ T cells are essential for the maintenance of CD8+ memory T (Tm) cells following acute infection, but the importance of CD4+ T cells for the maintenance and expansion of CD8+ Tm cells to non-infectious antigens remains mostly unknown. Here, we showed that ovalbumin (OVA)-specific CD8+ Tm cell precursors derived from in vitro stimulation of TCR transgenic OT I CD8+ T cells with OVA protein-pulsed bone marrow-derived dendritic cells (DCOVA) can give rise to functional CD8+ Tm cells after adoptively transferred into mice. These CD8+ Tm cells can be maintained and remain fully functional in CD4+ T cell-absent environments in vivo. Furthermore, CD4+ T cells are not essential for the expansion of these CD8+ Tm cells. Finally, these in vitro DCOVA-activated CD8+ Tm cells maintained in CD4-deficient mice are also able to confer fully protective immunity against a later challenge of OVA-expressing tumor cells. Collectively, these findings demonstrate that in contrast to acute infections, maintenance and expansion of CD8+ Tm cells after priming with OVA protein-pulsed dendritic cells are independent of CD4+ T cells.

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Citations

Apr 25, 2012·Cancer Immunology, Immunotherapy : CII·Hui-Ming ChenNing-Sun Yang
May 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koushik RoySyamal Roy
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siguo HaoJim Xiang
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siguo HaoJim Xiang

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