CD4+ T-cell lymphopenia in Q fever endocarditis.

Clinical and Diagnostic Laboratory Immunology
F SabatierJ Sampol

Abstract

Valvular endocarditis is the most serious complication of chronic Q fever, an infectious disease due to Coxiella burnetii. Although its pathogenesis is poorly understood, the role of the immune system has been evoked. The aim of this study was to investigate lymphocyte subsets in the peripheral blood of infected patients by analyzing the distribution of T- and B-lymphocyte subsets. Since various infectious diseases have been found to be associated with modified antigen expression, we also measured the antigen density of the main lymphocyte markers by quantitative flow cytometry. The absolute values of CD3+ T cells and CD19+ B cells were lower in infected subjects than in controls. The decrease in the CD4+ T-cell count was more pronounced than that in the CD8+ T-cell count, leading to a significantly lower CD4/CD8 ratio in patients. The decreases in CD4+ T cells and CD19+ B cells were correlated with levels of C. burnetii-specific immunoglobulin G, showing that CD4+ lymphopenia is related to the activity of chronic Q fever. Quantitation of antigen expression on lymphocytes showed that CD3, CD4, CD8, and CD19 were expressed similarly in patients and controls. In contrast, CD2 and CD11a expression levels, which are both related to...Continue Reading

References

Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D RaoultJ A Gastaut
Jan 1, 1990·Annals of the New York Academy of Sciences·D Raoult
Dec 1, 1985·The Journal of Infectious Diseases·F T KosterJ S Goodwin
Dec 1, 1989·European Journal of Epidemiology·P LevyJ J Razongles
Nov 1, 1984·The Journal of Infectious Diseases·B J LuftJ S Remington
Nov 1, 1983·The American Journal of Medicine·R C WilliamsK A Kilpatrick
Mar 1, 1994·Clinical and Diagnostic Laboratory Immunology·H T DupontD Raoult
Jan 1, 1993·AIDS·D RaoultJ Salducci

❮ Previous
Next ❯

Citations

Jan 9, 2001·Clinical Microbiology Reviews·P Brouqui, D Raoult
Jul 23, 2003·Infection and Immunity·Masako AndohKatsuya Hirai
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Jun 23, 2009·Annals of the New York Academy of Sciences·Eric GhigoJean-Louis Mege
Oct 9, 1999·Clinical Microbiology Reviews·M Maurin, D Raoult
Feb 16, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Florence FenollarDidier Raoult
Jul 3, 1998·Journal of Clinical Microbiology·P E FournierD Raoult
Mar 29, 2005·The Lancet Infectious Diseases·D RaoultJl Mege
Jul 30, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Bonnie Ann SarrellBeatrice P Concepcion
Oct 31, 2009·Veterinary Microbiology·Emmanouil Angelakis, Didier Raoult

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.