CD4(+) T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines

Frontiers in Immunology
Annalisa CiabattiniDonata Medaglini

Abstract

T cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4(+) T cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major challenge in the study of in vivo T cell priming is due to the low frequency of antigen-specific T cells. This review discusses the current knowledge on antigen-specific CD4(+) T cell priming in the context of vaccination, as well as the most advanced tools for the characterization of the in vivo T cell priming and the opportunities offered by the application of systems biology.

Citations

Nov 12, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Simone LucchesiAnnalisa Ciabattini
Feb 16, 2018·Immunologic Research·Katherine V Gates, Leigh G Griffiths
Oct 27, 2016·Frontiers in Immunology·Annalisa CiabattiniDonata Medaglini
Mar 30, 2018·Frontiers in Immunology·Annalisa CiabattiniDonata Medaglini
Jul 25, 2019·Frontiers in Microbiology·Annalisa CiabattiniDonata Medaglini
Aug 4, 2021·PLoS Computational Biology·Kenneth Y WertheimTomáš Helikar

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