Abstract
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate with immunity, and, therefore, PfEMP-1 may be a good candidate for a malaria vaccine. However, the specificity of CD4 T cells required for a protective variant-specific antibody response is not known. We have measured the CD4 T cell response to 3 different regions that are relatively homologous among different PfEMP-1 variants. The response to the cysteine-rich interdomain region was unusual in that the majority of donors, whether malaria exposed or not, had positive CD4 T cell, interleukin-10, and interferon-gamma responses. The CD4 T cell response to the exon 2 and duffy binding-like domain proteins was significantly greater in malaria-exposed donors than in unexposed Europeans, which suggests that these regions contain peptides recognized by T cells, which thus may be useful as components of a vaccine.
Citations
Jan 30, 2004·Molecular and Biochemical Parasitology·Kirsten Flick, Qijun Chen
May 24, 2003·Trends in Parasitology·Michelle L GattonQin Cheng
Aug 24, 2004·Infection and Immunity·Daria DonatiMaria Teresa Bejarano
Nov 22, 2005·Infection and Immunity·Kim BrustoskiAdrian J F Luty
Oct 10, 2006·Malaria Journal·Tatiane R OliveiraIrene S Soares
Jan 25, 2012·PloS One·Evelyn N GitauBritta C Urban
Apr 3, 2014·Cellular and Molecular Life Sciences : CMLS·Jo-Anne ChanJames G Beeson
Jan 30, 2007·Parasitology International·Padmalaya DasVirander S Chauhan
Sep 24, 2005·Parasite Immunology·F M NdunguJ Langhorne
Jan 28, 2006·Parasite Immunology·R Stephens, J Langhorne
Nov 17, 2007·Cell Host & Microbe·Marthe C D'OmbrainLouis Schofield
Jun 12, 2002·Malaria Journal·Latifu A SanniJean Langhorne
Dec 13, 2006·PLoS Pathogens·Kirsty C NewmanEleanor M Riley
May 20, 2016·Cellular and Molecular Life Sciences : CMLS·Jo-Anne ChanJames G Beeson
Sep 1, 2017·Molecular BioSystems·Nazam KhanUmar Farooq
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Evelyn N GitauBritta C Urban
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis M NdunguJean Langhorne