CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas

The Journal of Infectious Diseases
C E AllsoppJ Langhorne

Abstract

Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate with immunity, and, therefore, PfEMP-1 may be a good candidate for a malaria vaccine. However, the specificity of CD4 T cells required for a protective variant-specific antibody response is not known. We have measured the CD4 T cell response to 3 different regions that are relatively homologous among different PfEMP-1 variants. The response to the cysteine-rich interdomain region was unusual in that the majority of donors, whether malaria exposed or not, had positive CD4 T cell, interleukin-10, and interferon-gamma responses. The CD4 T cell response to the exon 2 and duffy binding-like domain proteins was significantly greater in malaria-exposed donors than in unexposed Europeans, which suggests that these regions contain peptides recognized by T cells, which thus may be useful as components of a vaccine.

Citations

Jan 30, 2004·Molecular and Biochemical Parasitology·Kirsten Flick, Qijun Chen
May 24, 2003·Trends in Parasitology·Michelle L GattonQin Cheng
Aug 24, 2004·Infection and Immunity·Daria DonatiMaria Teresa Bejarano
Apr 3, 2014·Cellular and Molecular Life Sciences : CMLS·Jo-Anne ChanJames G Beeson
Sep 24, 2005·Parasite Immunology·F M NdunguJ Langhorne
Jan 28, 2006·Parasite Immunology·R Stephens, J Langhorne
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Evelyn N GitauBritta C Urban
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis M NdunguJean Langhorne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.