CD4+ T Cell Subsets and Pathways to HIV Latency

AIDS Research and Human Retroviruses
Luis M Agosto, Andrew J Henderson

Abstract

Latent infection of CD4+ T cells is the main barrier to eradicating HIV-1 infection from infected patients. The cellular and molecular mechanisms involved in the establishment and maintenance of latent infection are directly linked to the transcriptional program of the different CD4+ T cell subsets targeted by the virus. In this review, we provide an overview of how T cell activation, T cell differentiation into functional subsets, and the mode of initial viral infection influence HIV proviral transcription and entry into latency.

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Citations

May 23, 2019·PLoS Pathogens·Matthew GagneAndrew J Henderson
May 24, 2020·Viruses·Ashutosh ShuklaIván D'Orso
Sep 2, 2019·Current Opinion in Virology·Alex OlsonAndrew J Henderson
Feb 7, 2021·International Immunopharmacology·Yue CaoXiaohong Tian

Methods Mentioned

BETA
nucleotide exchange

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