CD4+ T Cell Subsets and Pathways to HIV Latency

AIDS Research and Human Retroviruses
Luis M Agosto, Andrew J Henderson


Latent infection of CD4+ T cells is the main barrier to eradicating HIV-1 infection from infected patients. The cellular and molecular mechanisms involved in the establishment and maintenance of latent infection are directly linked to the transcriptional program of the different CD4+ T cell subsets targeted by the virus. In this review, we provide an overview of how T cell activation, T cell differentiation into functional subsets, and the mode of initial viral infection influence HIV proviral transcription and entry into latency.


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Methods Mentioned

nucleotide exchange

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