CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.

Mucosal Immunology
R A DrummondG D Brown

Abstract

Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin-1 is essential for driving fungal-specific CD4(+) T-cell responses in the GI tract. Loss of Dectin-1 resulted in abrogated dendritic cell responses in the mesenteric lymph nodes (mLNs) and defective T-cell co-stimulation, causing substantial increases in CD4(+) T-cell apoptosis and reductions in the cellularity of GI-associated lymphoid tissues. CD8(+) T-cell responses were unaffected by Dectin-1 deficiency. These functions of Dectin-1 have significant implications for our understanding of intestinal immunity and susceptibility to fungal infections.

References

Jan 19, 2000·The Journal of Experimental Medicine·K MurataK Sugamura
Apr 26, 2000·The Journal of Biological Chemistry·K AriizumiA Takashima
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip R TaylorSimon Y C Wong
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulf YrlidG Gordon MacPherson
Jul 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robin LesleyJason G Cyster
Dec 13, 2006·Nature Immunology·Philip R TaylorGordon D Brown
Apr 24, 2007·Nature Immunology·Salomé LeibundGut-LandmannCaetano Reis e Sousa
Aug 20, 2008·The Journal of Experimental Medicine·Elin JaenssonWilliam W Agace
Feb 19, 2009·Current Opinion in Immunology·Delyth M ReidGordon D Brown
Mar 24, 2009·The Journal of Hospital Infection·L N MirandaA S Levin
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L WernerChad Steele
Jul 21, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theo S PlantingaMihai G Netea
Aug 26, 2009·The Journal of Experimental Medicine·Matthew J RobinsonCaetano Reis e Sousa
Oct 30, 2009·The New England Journal of Medicine·Bart FerwerdaMihai G Netea
Mar 3, 2010·Immunological Reviews·Simon MillingGordon MacPherson
Mar 31, 2010·The Journal of Experimental Medicine·Brian T EdelsonKenneth M Murphy
Jun 17, 2011·Nature·Kevin J Maloy, Fiona Powrie
Dec 22, 2011·Current Opinion in Lipidology·Carolien OutGemma Brufau
Jun 22, 2012·Mucosal Immunology·V CerovicS W F Milling
Aug 23, 2012·Nature Immunology·Sarah E Hardison, Gordon D Brown
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
May 24, 2013·Nature·Keisha FindleyJulia A Segre
Sep 11, 2013·The Journal of Experimental Medicine·Nathan E WeltyDaniel H Kaplan

❮ Previous
Next ❯

Citations

Mar 18, 2016·Immunity·Siamon Gordon
Apr 20, 2016·Frontiers in Cellular and Infection Microbiology·Rebecca A Drummond, Michail S Lionakis
Mar 28, 2018·Nature Reviews. Immunology·Gordon D BrownLauren Whitehead
Dec 20, 2017·Frontiers in Immunology·Samuel Maldonado, Patricia Fitzgerald-Bocarsly
May 17, 2018·Journal of Innate Immunity·Fabián Salazar, Gordon D Brown
Oct 4, 2019·European Journal of Immunology·Kazuya ToneGordon D Brown
Apr 10, 2019·Journal of Leukocyte Biology·Ce TangYoichiro Iwakura
Jun 20, 2018·Frontiers in Immunology·Surabhi GoyalHortense Slevogt
Dec 31, 2020·Journal of Fungi·Leandro C D BredaSandro Rogério de Almeida
Apr 26, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Margaret R DunneThomas R Rogers
May 6, 2021·International Journal of Molecular Sciences·Mark Joseph Maranan DesameroShigeru Kakuta
Oct 26, 2016·Microbiology Spectrum·Gordon D Brown, Paul R Crocker

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
flow cytometry
fluorescence-activated cell sorting
PCR
fluorescence-activated
enzyme-linked immunosorbent assay

Software Mentioned

FlowJo

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2021 Meta ULC. All rights reserved