CD4+ T cells from IL-10-deficient mice transfer susceptibility to NSAID-induced Rag colitis

American Journal of Physiology. Gastrointestinal and Liver Physiology
Arthur M BlumJoel V Weinstock

Abstract

Products of arachidonic acid metabolism are important for mucosal homeostasis, because blockade of this pathway with an NSAID triggers rapid onset of severe colitis in the IL-10 knockout (IL-10(-/-)) model of IBD. Rag mice do not make T or B cells. This study determined whether reconstitution of Rag mice with T cells from IL-10(-/-) mice transferred NSAID colitis susceptibility. Rag mice were reconstituted by intraperitoneal injection with splenocytes from wild-type (WT) or IL-10(-/-) animals. Colitis was induced by using piroxicam and was graded histologically. Isolated lamina propria mononuclear cells (LPMC), lamina propria T cells, and LPMC depleted of T cells from reconstituted Rag mice were studied for cytokine production. Only animals reconstituted with IL-10(-/-) CD4(+) T cells and administered piroxicam developed severe colitis. LPMC from these colitic animals made IFN-gamma, whose production was dependent on T cells. Some IL-10 was produced but only from non-T cells. LPMC from the healthy Rag mice that were reconstituted with WT T cells and were piroxicam resistant made much more IL-10. This was mostly T cell dependent. In conclusion, only CD4(+) T cells from IL-10(-/-) animals leave Rag mice susceptible to NSAID-induc...Continue Reading

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Citations

Oct 12, 2012·Seminars in Immunopathology·Lisa A ReynoldsRick M Maizels
Nov 17, 2011·Protoplasma·Rose A K WhelanSebastian Rausch
Nov 21, 2007·Experimental Hematology·Kazue Tsuji-TakayamaMasayoshi Kibata
Nov 28, 2012·International Journal for Parasitology·Joel V Weinstock, David E Elliott
Jul 12, 2011·The American Journal of Pathology·Dominik BettenworthAndreas Lügering
Jul 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ahmed MetwaliJoel V Weinstock
May 4, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·C B LarmonierP R Kiela
Mar 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Long HangJoel V Weinstock
Aug 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Long HangJoel V Weinstock
Jan 9, 2019·Frontiers in Immunology·Damian MasedaLeslie J Crofford
Jul 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arthur M BlumJoel V Weinstock

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