CD4 T cells from malaria-nonexposed individuals respond to the CD36-Binding Domain of Plasmodium falciparum erythrocyte membrane protein-1 via an MHC class II-TCR-independent pathway.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Francis M NdunguJean Langhorne

Abstract

We have studied the human CD4 T cell response to a functionally conserved domain of Plasmodium falciparum erythrocyte membrane protein-1, cysteine interdomain region-1alpha (CIDR-1alpha). Responses to CIDR-1alpha were striking in that both exposed and nonexposed donors responded. The IFN-gamma response to CIDR-1alpha in the nonexposed donors was partially independent of TCR engagement of MHC class II and peptide. Contrastingly, CD4 T cell and IFN-gamma responses in malaria-exposed donors were MHC class II restricted, suggesting that the CD4 T cell response to CIDR-1alpha in malaria semi-immune adults also has a TCR-mediated component, which may represent a memory response. Dendritic cells isolated from human peripheral blood were activated by CIDR-1alpha to produce IL-12, IL-10, and IL-18. IL-12 was detectable only between 6 and 12 h of culture, whereas the IL-10 continued to increase throughout the 24-h time course. These data strengthen previous observations that P. falciparum interacts directly with human dendritic cells, and suggests that the interaction between CIDR-1alpha and the host cell may be responsible for regulation of the CD4 T cell and cytokine responses to P. falciparum-infected erythrocytes reported previously.

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Citations

Jan 28, 2006·Parasite Immunology·R Stephens, J Langhorne
Feb 26, 2019·Frontiers in Immunology·Jonas A Kengne-OuafoBismarck Dinko
Mar 31, 2020·European Journal of Immunology·Racheal AyeFrancis M Ndungu
May 29, 2012·Anais Da Academia Brasileira De Ciências·Laura N CruzCélia R S Garcia
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
Jul 9, 2010·Journal of Leukocyte Biology·Matthew B B McCall, Robert W Sauerwein
Apr 3, 2014·Cellular and Molecular Life Sciences : CMLS·Jo-Anne ChanJames G Beeson
Dec 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hernando CurtidorManuel E Patarroyo

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