CD4+ T cells mediate superantigen-induced abnormalities in murine jejunal ion transport

The American Journal of Physiology
D M McKayJ Lu

Abstract

The immunomodulatory properties of bacterial superantigens (SAgs) have been defined, yet comparatively little is known of how SAgs may affect enteric physiology. Staphylococcus aureus enterotoxin B (SEB) was used to examine the ability of SAgs to alter epithelial ion transport. BALB/c mice, severe combined immunodeficient (SCID, lack T cells) mice, or SCID mice reconstituted with lymphocytes or CD4+ T cells received SEB intraperitoneally, and jejunal segments were examined in Ussing chambers; controls received saline only. Baseline short-circuit current (Isc, indicates net ion transport) and Isc responses evoked by electrical nerve stimulation, histamine, carbachol, or forskolin were recorded. Serum levels of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) were measured. SEB-treated BALB/c mice showed elevated serum IL-2 and IFN-gamma levels, and jejunal segments displayed a time- and dose-dependent increase in baseline Isc compared with controls. Conversely, evoked ion secretion was selectively reduced in jejunum from SEB-treated mice. Elevated cytokine levels and changes in jejunal Isc were not observed in SEB-treated SCID mice. In contrast, SCID mice reconstituted with T cells were responsive to SEB challenge as shown ...Continue Reading

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Citations

Nov 25, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Keishi KojimaEugene B Chang
Aug 30, 2020·Journal of Animal Physiology and Animal Nutrition·Prabhu BalanPaul J Moughan
Mar 16, 2002·Infection and Immunity·Jeffrey W ShuppCarol H Pontzer
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·K G DickmanR D Shaw

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