CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice

Vaccine
Kelly A CunninghamKenneth W Beagley

Abstract

Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-gamma response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naïve mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.

References

Jul 24, 2002·International Journal of Antimicrobial Agents·Visnja SkerkAdriana Vince
Jun 24, 2004·Infection and Immunity·Sukumar PalLuis M de la Maza
Oct 24, 2007·Fertility and Sterility·Guadalupe GallegosJosé Luis Fernández
May 16, 2008·Biology of Reproduction·Kelly A Cunningham, Kenneth W Beagley
Jun 6, 2008·Vaccine·Ian Francis Cook
Aug 1, 2008·Clinical and Vaccine Immunology : CVI·Xiuli ZhangLbachir BenMohamed
Sep 23, 2008·American Journal of Reproductive Immunology : AJRI·Kelly A CunninghamKenneth W Beagley
May 13, 2009·The Journal of Infectious Diseases·Richard T GrayDavid P Wilson

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Citations

Jan 22, 2014·Immunology and Cell Biology·Charles W ArmitageKenneth W Beagley
May 16, 2014·Immunology·Charles W ArmitageKenneth W Beagley
Feb 11, 2021·American Journal of Reproductive Immunology : AJRI·Emily R BryanAlison J Carey

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