Abstract
Vaccination strategies incorporating the immunodominant HLA-A2-restricted HER2/neu-derived peptide 369-377 (HER2369-377) are increasingly utilized in HER2/neu-expressing cancer patients. The failure of postvaccination HER2369-377-specific CD8(+) T cells to recognize HLA-A2(pos)HER2/neu-expressing cells in vitro, however, has been attributed to impaired MHC class I/HLA-A2 presentation observed in HER2/neu-overexpressing tumors. We reconcile this controversy by demonstrating that HER2369-377 is directly recognized by high functional-avidity HER2369-377-specific CD8(+) T cells-either genetically modified to express a novel HER2369-377 TCR or sensitized using HER2369-377-pulsed type 1-polarized dendritic cells (DC1)-on class I-abundant HER2(low), but not class I-deficient HER2(high), cancer cells. Importantly, a critical cooperation between CD4(+) T-helper type-1 (Th1) cytokines IFNγ/TNFα and HER2/neu-targeted antibody trastuzumab is necessary to restore class I expression in HER2(high) cancers, thereby facilitating recognition and lysis of these cells by HER2369-377-specific CD8(+) T cells. Concomitant induction of PD-L1 on HER2/neu-expressing cells by IFNγ/TNF and trastuzumab, however, has minimal impact on DC1-sensitized HER2369...Continue Reading
References
Jun 1, 1995·The Journal of Experimental Medicine·B FiskC G Ioannides
Feb 1, 1997·Human Immunology·J LustgartenL A Sherman
Jan 7, 2000·Journal of Cellular Physiology·S MénardS M Pupa
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MénardE Tagliabue
Mar 1, 2003·Nature·Hyun-Soo ChoDaniel J Leahy
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuwen XuBrian J Czerniecki
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takanori KanaiMamoru Watanabe
Jan 20, 2004·Cancer Research·Felix HerrmannBarbara Seliger
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph A RitterCarlos L Arteaga
Nov 17, 2007·Cancer Research·Gabriela AlexeGyan Bhanot
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heinke ConradHelga Bernhard
Sep 30, 2008·Cancer Immunology, Immunotherapy : CII·Simona VertuaniRolf Kiessling
Apr 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda C BenavidesGeorge E Peoples
Apr 23, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert E RosesBrian J Czerniecki
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paula R PohlmannRay Mernaugh
Aug 18, 2010·International Journal of Cancer. Journal International Du Cancer·Kousaku MimuraRolf Kiessling
May 3, 2011·Trends in Biochemical Sciences·Michelle C MendozaJohn Blenis
Dec 30, 2011·Immunobiology·Jiao ChenPing Zhang
Jul 17, 2012·Molecular Medicine Reports·Guo-Sheng WangShi-Jie Bi
Nov 22, 2012·Oncoimmunology·Masayuki InoueKoji Kono
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kousaku MimuraKoji Kono
Jan 25, 2014·British Journal of Cancer·E AlbaA Lluch
Feb 20, 2014·PloS One·Hatem SolimanScott Antonia
Jul 9, 2014·Human Gene Therapy·Evripidis LanitisDaniel J Powell
Citations
May 21, 2015·Targeted Oncology·Gregory BenedettoChristine Richardson
Jun 18, 2015·Frontiers in Immunology·Jashodeep DattaBrian J Czerniecki
May 23, 2015·Breast Cancer Research : BCR·Jashodeep DattaBrian J Czerniecki
Oct 22, 2016·Frontiers in Pharmacology·Nadia F NoceraBrian J Czerniecki
Nov 6, 2015·Scientific Reports·Takumi KumaiHiroya Kobayashi
Feb 7, 2018·Disease Markers·Martina Di ModicaTiziana Triulzi
Jan 10, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Atefeh ArabJavad Behravan
Nov 2, 2019·Oncotarget·Prachi NamjoshiGary K Koski
May 26, 2018·Oncotarget·Cinthia RosemblitBrian J Czerniecki
May 2, 2018·Oncoimmunology·Lea LowenfeldBrian J Czerniecki
Jan 10, 2019·World Journal of Clinical Oncology·Shenghui QinGavin Y Wang
Sep 3, 2019·Frontiers in Immunology·Krithika N KodumudiBrian J Czerniecki
Mar 24, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thi TranEric Tartour
Apr 17, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kalijn F BolCarl G Figdor
Dec 19, 2020·Cancer Cell·Giulia PetroniLorenzo Galluzzi
May 21, 2021·Frontiers in Immunology·Amrita BasuKrithika Kodumudi
Aug 28, 2021·Journal of Personalized Medicine·Anna BurguinFrancine Durocher