Abstract
CD40 ligand (CD40L) is a trimeric, transmembrane protein of the tumor necrosis factor family and together with its receptor CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis, plaque destabilization, and thrombosis. In order to assess the association between serum concentrations of CD40 ligand (CD40L) and risk of future ischemic stroke and coronary events among patients with chronic CHD, we obtained baseline serum samples from patients (n = 3090) with chronic CHD enrolled in a secondary prevention trial. With a prospective nested case-control design, we measured baseline CD40L concentration in sera of patients who subsequently developed myocardial infarction, sudden cardiac death or ischemic stroke during follow-up (cases, n = 233) and in 233 age- and gender-matched pairs without any subsequent cardiovascular events. Relative odds for recurrent cardiovascular events per one natural log unit difference of CD40L were 0.97 (95%CI, 0.82-1.16). No increase in relative odds for recurrent cardiovascular events was observed per increasing quartiles of CD40L concentrations. In analysis for individual end-points, different trends of risks were observed beyond the 95 percentile for ischemic stroke ...Continue Reading
References
May 1, 1997·Stroke; a Journal of Cerebral Circulation·M I ChimowitzM D Gross
Jul 22, 1998·Nature·F MachP Libby
Jan 14, 1999·The New England Journal of Medicine·R Ross
Nov 5, 1999·Nature Medicine·E LutgensR A Flavell
Mar 25, 2000·The New England Journal of Medicine·P M RidkerN Rifai
Jul 6, 2000·Circulation·UNKNOWN Bezafibrate Infarction Prevention (BIP) study
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·N S RostP W Wilson
Nov 7, 2001·Circulation·U SchönbeckP M Ridker
Dec 12, 2001·Circulation Research·U Schönbeck, P Libby
Feb 14, 2002·Trends in Cardiovascular Medicine·Esther Lutgens, Mat J A P Daemen
Mar 30, 2002·Journal of the American College of Cardiology·Moti HaimSolomon Behar
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·E van ExelR G J Westendorp
Aug 21, 2002·Circulation·Patrick AndréDavid R Phillips
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·David TanneSolomon Behar
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Mária T MagyarDániel Bereczki
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·David TanneBen-Ami Sela
Mar 21, 2003·The New England Journal of Medicine·Jane E Freedman
Apr 19, 2003·Circulation·J David CurbRussell P Tracy
Jun 20, 2003·The New England Journal of Medicine·Leonard KritharidesBen Freedman
Jun 25, 2003·Circulation·Jie J CaoMary Cushman
Aug 13, 2003·Circulation·Nerea VaroUwe Schönbeck
Citations
Feb 11, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Guangde YangRong Lin
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Yu LiuQiaoli Ji
Aug 30, 2007·Cardiology·Matthew T RondinaJeffrey L Anderson
Apr 28, 2010·Journal of Ethnopharmacology·Hui ZhangLi-Na Yang
Mar 5, 2009·Neuroscience·S S KassnerR Kinscherf
Jan 11, 2007·Atherosclerosis·Gulcin AkinciBilgin Ozmen
Oct 16, 2015·Thrombosis and Haemostasis·T GremmelSimon Panzer
Oct 27, 2006·Pharmacotherapy·Issam ZinehRichard S Schofield
Jul 13, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Efthimios D AvgerinosChristos D Liapis
Apr 13, 2013·International Journal of Cardiology·Regent LeeKeith M Channon
Aug 15, 2009·Journal of the American College of Cardiology·Charalambos AntoniadesChristodoulos Stefanadis
May 14, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Patrícia NapoleãoTeresa Pinheiro
Aug 4, 2015·PloS One·Thomas GremmelAlan D Michelson
Sep 9, 2006·Current Opinion in Lipidology·Nicola FerriAlberto Corsini
Dec 3, 2008·Clinical Chemistry·Michaela PlaiknerJohannes Mair
Jan 20, 2011·Annals of Medicine·Burak PamukcuEduard Shantsila
Feb 17, 2007·Acta Pharmacologica Sinica·Jin-Chuan YanDan Luo
Oct 30, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Fabio AngeliClaudio Cavallini