CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease

International Journal of Cardiology
David TanneSolomon Behar

Abstract

CD40 ligand (CD40L) is a trimeric, transmembrane protein of the tumor necrosis factor family and together with its receptor CD40 is an important contributor to the inflammatory processes that lead to atherosclerosis, plaque destabilization, and thrombosis. In order to assess the association between serum concentrations of CD40 ligand (CD40L) and risk of future ischemic stroke and coronary events among patients with chronic CHD, we obtained baseline serum samples from patients (n = 3090) with chronic CHD enrolled in a secondary prevention trial. With a prospective nested case-control design, we measured baseline CD40L concentration in sera of patients who subsequently developed myocardial infarction, sudden cardiac death or ischemic stroke during follow-up (cases, n = 233) and in 233 age- and gender-matched pairs without any subsequent cardiovascular events. Relative odds for recurrent cardiovascular events per one natural log unit difference of CD40L were 0.97 (95%CI, 0.82-1.16). No increase in relative odds for recurrent cardiovascular events was observed per increasing quartiles of CD40L concentrations. In analysis for individual end-points, different trends of risks were observed beyond the 95 percentile for ischemic stroke ...Continue Reading

References

May 1, 1997·Stroke; a Journal of Cerebral Circulation·M I ChimowitzM D Gross
Jan 14, 1999·The New England Journal of Medicine·R Ross
Nov 5, 1999·Nature Medicine·E LutgensR A Flavell
Jul 6, 2000·Circulation·UNKNOWN Bezafibrate Infarction Prevention (BIP) study
Nov 7, 2001·Circulation·U SchönbeckP M Ridker
Dec 12, 2001·Circulation Research·U Schönbeck, P Libby
Feb 14, 2002·Trends in Cardiovascular Medicine·Esther Lutgens, Mat J A P Daemen
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·E van ExelR G J Westendorp
Aug 21, 2002·Circulation·Patrick AndréDavid R Phillips
Mar 21, 2003·The New England Journal of Medicine·Jane E Freedman
Apr 19, 2003·Circulation·J David CurbRussell P Tracy
Jun 20, 2003·The New England Journal of Medicine·Leonard KritharidesBen Freedman
Aug 13, 2003·Circulation·Nerea VaroUwe Schönbeck

❮ Previous
Next ❯

Citations

Feb 11, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Guangde YangRong Lin
Jan 11, 2007·Atherosclerosis·Gulcin AkinciBilgin Ozmen
Jul 13, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Efthimios D AvgerinosChristos D Liapis
Apr 13, 2013·International Journal of Cardiology·Regent LeeKeith M Channon
Aug 15, 2009·Journal of the American College of Cardiology·Charalambos AntoniadesChristodoulos Stefanadis
May 14, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Patrícia NapoleãoTeresa Pinheiro
Sep 9, 2006·Current Opinion in Lipidology·Nicola FerriAlberto Corsini
Jan 20, 2011·Annals of Medicine·Burak PamukcuEduard Shantsila
Oct 30, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Fabio AngeliClaudio Cavallini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.