PMID: 8970958Dec 1, 1996Paper

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

Journal of Virology
J K WhitmireR Ahmed

Abstract

CD40 ligand is expressed on activated T cells and interacts with CD40 on B cells and monocytes. It is not known what role CD40 ligand plays in the generation of immune responses to viral infection. To address this issue, we examined virus-specific T- and B-cell responses in CD40 ligand-deficient (CD40L-/-) mice following infection with lymphocytic choriomeningitis virus (LCMV). We found that primary anti-LCMV specific antibody responses were severely impaired in CD40L-/- mice, with the defect being most striking for antibody of the immunoglobulin G1 (IgG1) isotype. Interestingly, low levels of LCMV-specific antibodies of the IgG2a, IgG2b, and IgG3 isotypes were made in the CD40L-/- mice, showing that IgG1 responses are totally dependent on CD40L but that at least some IgG2a, IgG2b, and IgG3 responses can be CD40L independent. However, unlike CD40L+/+ mice, CD40L-/- mice were unable to sustain virus-specific antibody responses and showed a gradual decline in serum antibody levels over time. The CD40L-/- mice were also deficient in the generation of memory B cells. In contrast to the severely impaired humoral responses, CD40L-/- mice generated potent virus-specific CD8+ cytotoxic T-lymphocyte responses after LCMV infection and we...Continue Reading

References

Dec 1, 1992·The Journal of Experimental Medicine·M K SpriggsW C Fanslow
May 7, 1992·Nature·R J ArmitageC R Maliszewski
Jan 1, 1980·Advances in Immunology·M J BuchmeierM B Oldstone
Jun 23, 1994·Nature·L L LauR Ahmed
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·E CastigliR S Geha
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R FuleihanR S Geha
Sep 1, 1993·European Journal of Immunology·R J ArmitageM R Alderson
Aug 1, 1994·Immunity·J XuR A Flavell
Nov 1, 1994·The Journal of Experimental Medicine·B R RenshawC R Maliszewski
Feb 11, 1993·Nature·J P DiSantoG de Saint Basile

❮ Previous
Next ❯

Citations

May 23, 1998·Annual Review of Immunology·I S Grewal, R A Flavell
Jun 22, 1999·The Journal of Experimental Medicine·C RuedlM F Bachmann
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A WilliamsC P Larsen
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R ThomsenJ P Christensen
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan NierkensRaymond Pieters
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew A WilliamsChristian P Larsen
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byung O LeeTroy D Randall
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Genevive H HernandezKenneth L Rock
Oct 23, 1997·Arthritis and Rheumatism·S K Datta, S L Kalled
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D M RothsteinG P Basadonna
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D MasopustL Lefrançois
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elissa K DeenickPhilip D Hodgkin
Dec 22, 1999·The Journal of Clinical Investigation·J TrambleyC P Larsen
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A WilliamsC P Larsen
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kelleher, P C Beverley
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcel WüthrichBruce S Klein
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Feb 15, 2011·Annual Review of Immunology·Shane Crotty
Jul 10, 2013·The Journal of Experimental Medicine·André Ballesteros-TatoTroy D Randall
Aug 29, 2020·International Journal of Molecular Sciences·Hyun-Su Lee, Gil-Saeng Jeong
Aug 18, 1999·Immunological Reviews·E A Green, R A Flavell
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E Szomolanyi-TsudaR L Garcea
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yasuo TakeuchiMegan Sykes
Feb 1, 1997·Immunologic Research·I S Grewal, R A Flavell
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N D JonesK J Wood
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byung O LeeTroy D Randall
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M EnsmingerK J Wood
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason K WhitmireRafi Ahmed
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Matteo IannaconeLuca G Guidotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.