CD40 ligand immunotherapy in cancer: an efficient approach

Leukemia & Lymphoma
N KuwashimaM Urashima

Abstract

Cancer cells do not elicit a clinically sufficient anti-tumor immune response that results in tumor rejection. Recently, many investigators have been trying to enhance anti-tumor immunity and encouraging results have been reported. This review will discuss current anti-cancer immunotherapy; interleukin-2 therapy, tumor vaccine secreting Granulocyte macrophage-colony stimulating factor, dendritic cells fused with tumor cells, and CD40 ligand immunotherapy. Moreover, we introduce our two kinds of CD40 ligand immuno-genetherapy; (1) oral CD40 ligand gene therapy against lymphoma using attenuated Salmonella typhimurium (published in BLOOD 2000), (2) cancer vaccine transfected with CD40 ligand ex vivo for neuroblastoma (unpublished). Both approaches resulted in a high degree of protection against the tumor progression and they are simple and safe in the murine system.

Citations

Sep 22, 2005·Cancer Immunology, Immunotherapy : CII·Angelica LoskogThomas H Tötterman
Dec 1, 2006·Current Hematologic Malignancy Reports·Renier J Brentjens
Aug 5, 2004·Current Oncology Reports·Renier J Brentjens
Mar 9, 2005·Thyroid : Official Journal of the American Thyroid Association·Amy CostelloGary L Francis
Jul 10, 2004·Clinical and Diagnostic Laboratory Immunology·Dimitris DaoussisStamatis-Nick C Liossis
Jan 17, 2020·Scientific Reports·Taha ElmetwaliDaniel H Palmer

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