CD40 signaling induces interleukin-4-independent IgE switching in vivo

European Journal of Immunology
W G FerlinM C Howard

Abstract

T cell-deficient T cell receptor (TCR) beta-/- x TCR delta-/- knockout mice lack circulating IgE and fail to produce antigen-specific IgE in response to stimulation with T cell-dependent antigens. We show here that these animals are able to produce significant levels of circulating polyclonal IgE when injected with an agonistic anti-mouse CD40 monoclonal antibody. CD40-mediated induction of circulating polyclonal IgE in T cell-deficient mice was only partially reduced when the animals were co-treated with neutralizing anti-interleukin-4 (IL-4) antibody. The IL-4 independence of this response was further supported by experiments showing that anti-CD40 antibodies induced circulating IgE when injected into IL-4 knockout mice, and sterile RNA epsilon transcript production when cultured with purified B cells from the same mice. These data strongly suggest that CD40 signaling causes IL-4-independent IgE switching in mice.

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Citations

Jul 13, 2002·Pharmacology & Therapeutics·Paul S FosterDavid B Corry
May 16, 1998·The Journal of Experimental Medicine·N SolvasonM Howard
Oct 13, 2006·Current Opinion in Gastroenterology·S H Murch
Feb 28, 2002·Annual Review of Immunology·Tasuku HonjoMasamichi Muramatsu
May 1, 2006·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Tasuku HonjoReiko Shinkura
Jan 24, 2004·Clinical and Experimental Immunology·Z WuD B G Oliveira
Dec 10, 1999·Nature·D B Corry, F Kheradmand
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C S Mao, J Stavnezer
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Reif, J G Cyster

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