PMID: 7540860Mar 1, 1995Paper

CD40 signalling in ileal Peyer's patch B cells: implications for T cell-dependent antigen selection

International Immunology
P Griebel, G Ferrari

Abstract

The ileal Peyer's patch (PP) plays a central role in B cell development in young sheep and it is hypothesized that this B cell development occurs independent of extrinsic antigen and T cells. Therefore, it was of interest to examine ileal PP follicular (iPf) B cell responses to CD40 ligand, a molecule integral to T cell-dependent B cell development. A variable level of CD40 expression was detected on a subpopulation of iPfB cells and J558L cells, expressing a membrane form of mouse CD40 ligand (mCD40L), interacted specifically with the CD40 molecule on iPfB cells. In response to mCD40L the non-S phase iPfB cells were rescued from apoptotic cell death and there was a marked proliferative response but viable cell number remained relatively constant. The mCD40L also induced decreased cytoplasmic cAMP levels, blocked anti-Ig-induced iPfB cell death and induced functional IL-2 receptor expression on a subpopulation of iPfB cells. Many of the mCD40L-induced responses of iPfB cells were similar to those reported for germinal centre and immature B cells, and indicated that cognate T cell-B cell interaction could influence iPfB cell proliferation and differentiation. Finally, that mCD40L induced iPfB cell activation and differentiation ...Continue Reading

Citations

Jan 1, 1996·Immunology Today·P J Griebel, W R Hein
Aug 23, 2001·Journal of Immunological Methods·V GerdtsP J Griebel
Mar 22, 2000·Journal of Immunological Methods·P J GriebelW Hein
Aug 14, 1999·Immunology·H TakamatsuR M Parkhouse
Apr 20, 2006·Animal Biotechnology·John D NeillElizabeth Liebler-Tenorio
Jan 1, 1997·International Reviews of Immunology·J Reynolds
Apr 14, 2006·Veterinary Research·Elisabeth M Liebler-Tenorio, Reinhard Pabst
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharmila ManojSylvia van Drunen Littel-van den Hurk

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