PMID: 11309153Apr 20, 2001Paper

CD40L-induced IL-12 production is further enhanced by the Th2 cytokines IL-4 and IL-13

Scandinavian Journal of Immunology
D M BullensJ L Ceuppens

Abstract

Interaction of the CD40L (CD154) molecule on activated T cells with its receptor, CD40, on macrophages and dendritic cells (DC) provides a strong signal for interleukin (IL)-12 production. As IL-12 is the most important factor in driving Th precursor (Thp) cells into T(h)elper 1 cells, CD40-CD40L interactions strongly promote Th1 differentiation. Th2 cytokines (IL-4, IL-13, IL-10) on the other hand, are known to inhibit Th1 differentiation, and to promote either directly or indirectly, Th2 differentiation. Inhibition of lipopolysaccharide (LPS)-induced IL-12 production by IL-4, IL-13 and IL-10 is supposed to be one such mechanism. However, we here report that IL-4 and IL-13 enhance p70 IL-12 production and p40 mRNA transcription by human monocytes when the latter are stimulated trough triggering of CD40. This effect on IL-12 induction is most clear in the presence of interferon (IFN)-gamma, which upregulates CD40 expression. IL-10 potently inhibits IL-12 production. The increased IL-12 production in the presence of IL-4 and IL-13 is however, not the indirect result of a reduction in IL-10 production, but is most likely owing to a direct effect of IL-4 and IL-13. We conclude that IL-4 and IL-13 enhance rather than decrease the I...Continue Reading

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Citations

Sep 2, 2006·Cancer Immunology, Immunotherapy : CII·Jon Amund KyteGustav Gaudernack
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying QianM Reza Dana
Sep 1, 2004·Expert Opinion on Biological Therapy·Tara M Robinson, Jean D Boyer
Oct 22, 2008·Allergologia et immunopathologia·A KutluZ Kartaloglu
Jun 23, 2009·Seminars in Immunology·Jill Suttles, Robert D Stout
Aug 28, 2007·International Journal of Medical Microbiology : IJMM·Marcela Fajardo-MoserHeidrun Moll
Mar 28, 2007·Scandinavian Journal of Immunology·A KutluE Bozkanat
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Apr 3, 2008·The Journal of International Medical Research·A KutluO Taskapan
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Aug 26, 2006·Journal of Leukocyte Biology·Richard S Kornbluth, Geoffrey W Stone
Aug 21, 2007·European Journal of Immunology·Katharina A RemerHeidrun Moll
Jun 7, 2015·Journal of Leukocyte Biology·Bryan D FlemingDavid M Mosser
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne C MorrisFred D Finkelman
Jul 23, 2020·Frontiers in Immunology·Mikhail Petrovich KostinovAristitsa Mikhailovna Kostinova
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Jan 1, 2021·Frontiers in Oncology·Jane KooAlisa B Lee-Sherick

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