CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis.

Development
Julien Y BertrandDavid Traver

Abstract

Development of the vertebrate blood lineages is complex, with multiple waves of hematopoietic precursors arising in different embryonic locations. Monopotent, or primitive, precursors first give rise to embryonic macrophages or erythrocytes. Multipotent, or definitive, precursors are subsequently generated to produce the adult hematopoietic lineages. In both the zebrafish and the mouse, the first definitive precursors are committed erythromyeloid progenitors (EMPs) that lack lymphoid differentiation potential. We have previously shown that zebrafish EMPs arise in the posterior blood island independently from hematopoietic stem cells (HSCs). In this report, we demonstrate that a fourth wave of hematopoietic precursors arises slightly later in the zebrafish aorta/gonad/mesonephros (AGM) equivalent. We have identified and prospectively isolated these cells by CD41 (itga2b) and cmyb expression. Unlike EMPs, CD41(+) AGM cells colonize the thymus to generate rag2(+) T lymphocyte precursors. Timelapse imaging and lineage tracing analyses demonstrate that AGM-derived precursors use a previously undescribed migration pathway along the pronephric tubules to initiate adult hematopoiesis in the developing kidney, the teleostean equivalent ...Continue Reading

References

Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·N M Le DouarinM Belo
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K OzatoB M Orrison
Oct 1, 1967·The Journal of Experimental Medicine·M A Moore, J J Owen
Feb 1, 1969·The Journal of Experimental Medicine·J J Owen, M A Ritter
Aug 1, 1980·European Journal of Immunology·F V JotereauN M Le Douarin
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·H W DetrichL I Zon
Dec 1, 1993·Seminars in Cell Biology·T Woodford-Thomas, M L Thomas
Jan 1, 1996·Immunity·S Delassus, A Cumano
Oct 1, 1996·Current Opinion in Genetics & Development·S H Orkin
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·M C YoderP Mukherjee
May 26, 1999·Experimental Hematology·G KellerS Robertson
Apr 23, 2002·Nature Genetics·Amy J SehnertDidier Y R Stainier
Jul 12, 2002·Developmental Cell·Toshihiro MiyamotoKoichi Akashi
Feb 8, 2003·Science·David M LangenauA Thomas Look
Dec 4, 2003·FEMS Immunology and Medical Microbiology·Thierry JaffredoDominique Dunon
Jul 9, 2004·Developmental Cell·Koichi KawakamiMasayoshi Mishina
Oct 20, 2004·Methods in Molecular Medicine·Julien Y BertrandIsabelle Godin
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Julien Y BertrandAna Cumano
Mar 2, 2005·Developmental Cell·Christos GekasHanna K A Mikkola
Mar 2, 2005·Developmental Cell·Katrin Ottersbach, Elaine Dzierzak
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Jul 16, 2005·Blood·Julien Y BertrandIsabelle Godin
Aug 16, 2005·Blood·Hui-Feng LinRobert I Handin
Sep 17, 2005·Genes & Development·Caroline Erter BurnsLeonard I Zon
Nov 30, 2005·The Journal of Experimental Medicine·Azusa MatsubaraHiromitsu Nakauchi
Apr 14, 2006·Development·Takafumi YokotaPaul W Kincade
Jan 30, 2007·Nature Reviews. Immunology·Frank Rosenbauer, Daniel G Tenen
Mar 23, 2007·Nature·Igor M SamokhvalovShin-ichi Nishikawa

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Citations

Aug 23, 2011·Frontiers of Medicine·Panpan Zhang, Feng Liu
Jun 12, 2013·Developmental and Comparative Immunology·Barbara A KatzenbackMiodrag Belosevic
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Geanncarlo Lugo-VillarinoDavid Traver
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cristian Soza-RiedThomas Boehm
Apr 12, 2012·Stem Cells and Development·Junnian ZhouXuetao Pei
Mar 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael S Goligorsky
Jun 6, 2009·Current Opinion in Hematology·Julien Y Bertrand, David Traver
May 13, 2009·Blood·David L StachuraDavid Traver
Mar 17, 2011·Blood·Valerie WittamerDavid Traver
Sep 4, 2010·BMC Molecular Biology·Audrey Guillon-MunosDenis Rasschaert
Jun 29, 2011·Disease Models & Mechanisms·Lili Jing, Leonard I Zon
Aug 7, 2013·Blood Cells, Molecules & Diseases·Sonja BoatmanLeonard I Zon
Apr 2, 2014·Developmental and Comparative Immunology·Kanako L LewisDavid Traver
Jul 11, 2012·Advances in Hematology·Jill L O de Jong, Leonard I Zon
Jul 11, 2012·Advances in Hematology·Gauri KhandekarPudur Jagadeeswaran
Dec 10, 2015·Stem Cells and Development·Frank StaalWillem E Fibbe
Jan 24, 2016·Developmental and Comparative Immunology·Isao KobayashiTadaaki Moritomo
Jan 28, 2016·ELife·Aniket V GoreBrant M Weinstein
Jan 10, 2012·Developmental and Comparative Immunology·Dongyuan MaFeng Liu
Feb 16, 2010·Current Opinion in Immunology·Michelle Kanther, John F Rawls
Jan 1, 2009·Drug Discovery Today. Therapeutic Strategies·Teresa V Bowman, Leonard I Zon
Mar 3, 2009·Blood Cells, Molecules & Diseases·Nancy A Speck, M Luisa Iruela-Arispe
Dec 10, 2014·Developmental Cell·Suphansa SawamiphakDidier Y R Stainier
Jul 1, 2009·Journal of Cellular Biochemistry·Aye T Chen, Leonard I Zon
May 27, 2009·British Journal of Haematology·Elspeth Payne, Thomas Look
Jul 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lei WangTing Xi Liu
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Gary F Gerlach, Rebecca A Wingert

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