CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner

The Journal of Immunology : Official Journal of the American Association of Immunologists
Masanori MatsumotoTakako Hirata

Abstract

As the first step in the recruitment of neutrophils into tissues, the cells become tethered to and roll on the vessel wall. These processes are mediated by interactions between the P- and E-selectins, expressed on the endothelial cells of the vessel wall, and their ligands, expressed on the neutrophils. Recently, we reported that CD43 on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in collaboration with P-selectin glycoprotein ligand-1 (PSGL-1), a major P- and E-selectin ligand. Here, we examined whether CD43 on neutrophils also functions as an E-selectin ligand. CD43 was precipitated with an E-selectin-IgG chimera from mouse bone marrow neutrophils. A CD43 deficiency diminished the E-selectin-binding activity of neutrophils when PSGL-1 was also deficient. Intravital microscopy showed that the CD43 deficiency significantly increased leukocyte rolling velocities in TNF-alpha-stimulated venules blocked with an anti-P-selectin mAb, where the rolling was mostly E-selectin dependent, when PSGL-1 was also absent. In contrast, in venules with trauma-induced inflammation, where the rolling was largely P-selectin dependent, the CD43 deficiency reduced leukocyte rolling velo...Continue Reading

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Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori MatsumotoTakako Hirata

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Citations

Jan 25, 2012·Annals of Biomedical Engineering·S D ChaseS I Simon
Jun 15, 2019·Scientific Reports·Frederico Alisson-SilvaAdriane R Todeschini
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tadayuki YagoLijun Xia
Nov 3, 2011·Annals of Biomedical Engineering·Zélia SilvaPaula A Videira
Aug 26, 2009·Journal of Leukocyte Biology·Alexander ZarbockKlaus Ley
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori MatsumotoTakako Hirata
Nov 6, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Laura HertwigFriedemann Paul
Mar 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana SilvaRobert Sackstein
Aug 22, 2009·Glycobiology·Felipe L OliveiraMárcia C El-Cheikh
Jul 15, 2009·Immunological Reviews·Markus SperandioKlaus Ley
Nov 26, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew HughesMichael R King

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