Abstract
As the first step in the recruitment of neutrophils into tissues, the cells become tethered to and roll on the vessel wall. These processes are mediated by interactions between the P- and E-selectins, expressed on the endothelial cells of the vessel wall, and their ligands, expressed on the neutrophils. Recently, we reported that CD43 on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in collaboration with P-selectin glycoprotein ligand-1 (PSGL-1), a major P- and E-selectin ligand. Here, we examined whether CD43 on neutrophils also functions as an E-selectin ligand. CD43 was precipitated with an E-selectin-IgG chimera from mouse bone marrow neutrophils. A CD43 deficiency diminished the E-selectin-binding activity of neutrophils when PSGL-1 was also deficient. Intravital microscopy showed that the CD43 deficiency significantly increased leukocyte rolling velocities in TNF-alpha-stimulated venules blocked with an anti-P-selectin mAb, where the rolling was mostly E-selectin dependent, when PSGL-1 was also absent. In contrast, in venules with trauma-induced inflammation, where the rolling was largely P-selectin dependent, the CD43 deficiency reduced leukocyte rolling velo...Continue Reading
References
Sep 6, 1991·Cell·L J PickerE C Butcher
Feb 1, 1995·The Journal of Experimental Medicine·K LeyA L Beaudet
Feb 16, 1995·Nature·M SteegmaierD Vestweber
Jun 1, 1995·The Journal of Experimental Medicine·T F TedderP Pizcueta
Feb 23, 1996·Cell·P S FrenetteD D Wagner
May 1, 1996·The Journal of Cell Biology·C A LowellG Berton
Dec 1, 1996·Circulation Research·E J Kunkel, K Ley
Feb 10, 1997·The Journal of Cell Biology·O ZöllnerD Vestweber
Dec 8, 1998·The Journal of Experimental Medicine·R C WoodmanP Kubes
Dec 29, 1998·Immunology Today·J R OstbergJ G Frelinger
Jan 29, 1999·Physiological Reviews·D Vestweber, J E Blanks
Nov 26, 1999·Biochimica Et Biophysica Acta·M Fukuda, S Tsuboi
Dec 22, 1999·The Journal of Experimental Medicine·J YangB Furie
May 16, 2000·The Journal of Biological Chemistry·A NandiM H Siegelman
Jul 7, 2000·The Journal of Biological Chemistry·M C HuangD Vestweber
Dec 6, 2000·The Journal of Experimental Medicine·T HirataB Furie
Nov 24, 2001·Blood·S B ForlowK Ley
Sep 18, 2002·Immunological Reviews·John B Lowe
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuyuki AtarashiMasayuki Miyasaka
Apr 13, 2005·The Journal of Experimental Medicine·Yoshio KatayamaPaul S Frenette
Nov 5, 2005·Blood·Robert C FuhlbriggeThomas S Kupper
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori MatsumotoTakako Hirata
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas A Carlow, Hermann J Ziltener
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori MatsumotoTakako Hirata
Apr 20, 2007·Immunity·Andrés HidalgoPaul S Frenette
Citations
Mar 25, 2010·Histochemistry and Cell Biology·L LecceC R Murphy
Jan 25, 2012·Annals of Biomedical Engineering·S D ChaseS I Simon
Apr 27, 2013·British Journal of Haematology·Zdravko MitrovicWing C Chan
Jan 15, 2016·PloS One·Ashton Barnett-VanesSara Rankin
Jun 15, 2019·Scientific Reports·Frederico Alisson-SilvaAdriane R Todeschini
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tadayuki YagoLijun Xia
Nov 3, 2011·Annals of Biomedical Engineering·Zélia SilvaPaula A Videira
Aug 26, 2009·Journal of Leukocyte Biology·Alexander ZarbockKlaus Ley
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori MatsumotoTakako Hirata
Feb 20, 2010·Blood·Helena MuellerAlexander Zarbock
Nov 6, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Laura HertwigFriedemann Paul
Mar 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana SilvaRobert Sackstein
Aug 22, 2009·Glycobiology·Felipe L OliveiraMárcia C El-Cheikh
Jul 15, 2009·Immunological Reviews·Markus SperandioKlaus Ley
Nov 26, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew HughesMichael R King