CD44 as a potential diagnostic tumor marker

Saudi Medical Journal
Nawwaf S Basakran

Abstract

CD44 is a cellular protein that has been intensively studied in relation to carcinogenesis over the last decade. It is altered during inflammatory responses and cellular malfunctioning during tumor progression. Tumors of epithelial origin express CD44 in multiple isoforms called variants; some isoforms are related to specific cancer cells. An increase of CD44 specific isoforms is detected in certain leukemic proliferations. Most published data indicates a partial involvement of CD44 in cancer cells, either in invasiveness or self-renewability. However, there is still uncertainty regarding the exact mechanism by which CD44 participates in growth of cancer or the inflammatory response. This review focuses on CD44 prevalence in cancer cell. It considers tumorigenic behavior of cells that highly express CD44 as an early marker for neoplastic stem cell proliferation. We will discuss multiple examples of tumor in this paper, with an emphasis of 2 solid tumors; namely, breast and colon cancer.

Citations

Oct 12, 2016·Frontiers in Oncology·Christine E Cutucache, Tyler A Herek
Mar 11, 2017·BMC Medical Genomics·Orieta CelikuUma Shankavaram
Feb 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joel PardoRoger M Leblanc
Feb 21, 2018·Arkhiv patologii·N A OleynikovaN V Danilova
Jan 17, 2019·Organic & Biomolecular Chemistry·Sara R G FernandesJoão P C Tomé
Jul 25, 2019·Cell Communication and Signaling : CCS·Linda T SenbanjoMeenakshi A Chellaiah
Feb 26, 2019·Current Pharmaceutical Design·Pranathi TataKiran Kalia
Sep 25, 2017·Journal of Clinical Pathology·Matthew J MunroTinte Itinteang
Sep 9, 2017·Oncotarget·Zhang XipingDing Xiaowen
Mar 20, 2020·Current Pharmaceutical Design·Zhi-Xiang YuanJuchun Lin
Sep 30, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kanchan KumariSandip K Mishra
Mar 23, 2017·Frontiers in Cell and Developmental Biology·Linda T Senbanjo, Meenakshi A Chellaiah
Sep 5, 2018·Scientific Reports·Takayoshi ShirasakiShuichi Kaneko
Feb 14, 2019·Archives of Pharmacal Research·Sri Murugan Poongkavithai VadevooByungheon Lee
Jan 30, 2020·Scientific Reports·Prasad DandawateShrikant Anant
Aug 17, 2020·Biomolecules·Svenja Kleiser, Alexander Nyström
Feb 9, 2018·The Journal of Pathology. Clinical Research·Claudia Corrò, Holger Moch
Dec 14, 2018·Medical Sciences : Open Access Journal·Gökçe Güllü AmuranMustafa Akkiprik
Dec 19, 2020·Frontiers in Oncology·Antons MartincuksLorna Rodriguez-Rodriguez
Aug 14, 2020·Experimental Biology and Medicine·Sheron Campos CogoSelene Elifio-Esposito
Dec 15, 2020·World Journal of Stem Cells·Shao-Yu PengSteven W Shaw
Feb 20, 2021·Molecular and Cellular Biochemistry·Reihaneh Alsadat MahmoudianMehran Gholamin
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayeskanta MohantyIn-Kyu Park
Apr 18, 2021·Cell Biology and Toxicology·Sagarkumar PatelAmit Shard
Mar 3, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kevin MathaJean-Pierre Benoit
May 8, 2021·European Journal of Pharmacology·Zohreh YaghobiBehzad Baradaran
May 21, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Elizabeth CampbellAnton V Naumov
Jun 24, 2021·Brazilian Oral Research·Jamile Marinho Bezerra de Oliveira MouraLélia Batista de Souza
Jul 1, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Lingshan LiuHongjing Dou
Oct 2, 2021·Therapeutic Delivery·Jagadish NateshMuniasamy Neerathilingam
Nov 5, 2017·New Biotechnology·Felipe Marques Souza de OliveiraMasood Kamali-Moghaddam

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Methods Mentioned

BETA
antisense oligonucleotide

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