PMID: 8605724Mar 1, 1996Paper

CD44 exon variant 6 epitope and hyaluronate synthase are expressed on HT29 human colorectal carcinoma cells in a SCID mouse model of metastasis formation

Clinical & Experimental Metastasis
B S MitchellU Schumacher

Abstract

The factors which lead to the formation of metastases are generally poorly understood; however the expression of a particular variant of the cell adhesion molecule CD44 may be important in facilitating metastasis formation in colon cancer. The aim of the present study was to investigate the expression of CD44 exon v 6 (CD44v6), hyaluronate (one of its ligands), and hyaluronate synthase, in a clinically relevant animal model of metastatic colon carcinoma. HT29 human colon carcinoma cells were injected subcutaneously between the scapulae of severe combined immunodeficient (SCID) mice and left for 3 weeks (by which time the tumours had produced metastases in the lungs). Morphological observations at the tumour-host interface were consistent with the dissociation of neoplastic cells from the primary tumours, and the ability of these cells to migrate through the extracellular matrix facilitating metastasis formation. Immunohistochemically detectable hyaluronate synthase expression was increased in vivo compared with the parent cell line in vitro. CD44v6 expression and hyaluronate were increased around single cells at the periphery of tumours compared with the central regions. CD44v6 and hyaluronate snythase expression were co-expres...Continue Reading

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B P TooleJ Gross
Oct 15, 1986·The Biochemical Journal·M BrechtP Prehm
Jan 1, 1987·Annual Review of Medicine·S JalkanenE C Butcher
Jan 1, 1984·Journal of Cellular Biochemistry·W KnudsonB P Toole
Jun 1, 1984·The Biochemical Journal·P Prehm
Jul 1, 1994·The Journal of Experimental Medicine·A BartolazziI Stamenkovic
Feb 4, 1995·Lancet·K KoretzC Herfarth
Mar 3, 1995·International Journal of Cancer. Journal International Du Cancer·P RooneyM Wang
Nov 1, 1994·The Journal of Clinical Investigation·H L BumpersR B Bankert
Jan 1, 1993·The Biochemical Journal·M LansingP Prehm
Mar 15, 1993·The Biochemical Journal·L KlewesP Prehm

❮ Previous
Next ❯

Citations

Mar 10, 2001·Mechanisms of Ageing and Development·H M LeeE W Englander
Jan 1, 2002·Tobacco Induced Diseases·D A Scott, R M Palmer
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·B MytarM Zembala
Feb 14, 2007·Journal of Cellular Biochemistry·Man-Il HuhJae-Chang Jung
Sep 20, 2011·Journal of Cellular Biochemistry·Jelena JoergesPeter Prehm
May 23, 2006·Acta histochemica·Ulrika M SchadeUdo Schumacher
Nov 2, 2005·Ageing Research Reviews·Ella W Englander
Feb 22, 2005·Archives of Oral Biology·Sz FelszeghyL Módis
Apr 1, 1997·The Journal of Pathology·B Radotra, D McCormick
May 30, 1997·The Journal of Biological Chemistry·P H WeigelM Tammi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
H D OrzechowskiA Stallmach
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
E M KittlK Bauer
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
S E Fleming, R Gill
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
J I SparkR C Kester
© 2021 Meta ULC. All rights reserved