PMID: 7514617Feb 1, 1994Paper

CD44 expression in Merkel cell carcinoma may correlate with risk of metastasis

Journal of Cutaneous Pathology
N S Penneys, S Shapiro

Abstract

We retrospectively studied 25 cases of cutaneous primary, locally recurrent or metastatic Merkel cell carcinoma to see if expression of the cell surface marker CD44 correlated with metastatic potential. In 3 of 6 cases in which metastasis was documented, CD44 was found on membranes of tumor cells. Three cutaneous lesions associated with local metastasis did not express CD44. Three primary tumors expressed CD44 but had not disseminated at the time of this report; follow-up after excision of the primary lesion in these cases was less than 6 months. None of the primary or locally recurrent Merkel cell carcinomas followed longer than 6 months (14 of 19 cases) expressed CD44. We conclude that expression of CD44 in Merkel cell carcinoma may eventually be of some value in the assessment of prognosis of cutaneous Merkel cell carcinoma.

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Citations

Jun 1, 1993·Journal of Cutaneous Pathology·N S Penneys
Mar 21, 1998·Journal of Cutaneous Pathology·H J CarsonJ B Taxy
Aug 1, 1995·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M L HaagN A Fenske
Jun 7, 2011·Human Pathology·Satoshi Kuwamoto
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Kishor BhatiaLeona W Ayers
Feb 16, 2006·Actas dermo-sifiliográficas·Josep BertóFrancisco Sánchez de Paz
Feb 24, 2015·Clinics in Dermatology·Vivian T YinBita Esmaeli
Nov 24, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A L TuhkanenR H Tammi
Mar 22, 2001·Experimental Dermatology·K SamesI Moll
Nov 23, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·María-Teresa Fernández-FiguerasAurelio Ariza
Apr 18, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·B JemecA O Grobbelaar
Jan 1, 1995·Journal of Cellular Physiology·N Iida, L Y Bourguignon
May 14, 1998·Journal of Surgical Oncology·K F HelmR A Schwartz
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D Mehregan, D Mehregan
Mar 30, 2010·International Ophthalmology Clinics·Rhonda V Barrett, Dale R Meyer
Mar 26, 2003·Archives of Pathology & Laboratory Medicine·Michael O IdowuCeleste Powers

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