Abstract
CD44 is thought to be a principal cell surface receptor for hyaluronic acid. Although the distribution of hyalulonic acid has been studied, little is known about the distribution of the CD44 molecule in the human skin and skin tumors. This study was undertaken to investigate the distribution of the CD44 molecule in normal human skin as well as in benign and malignant skin tumors. In normal skin, CD44 was expressed on 1) keratinocyte cell surfaces throughout the epidermis except for the granular and horny layers, 2) hair follicular cells, 3) eccrine sweat gland cells, and 4) cell surfaces of dendritic cells in the dermis. In skin tumors, although CD44 was expressed on the tumor cell surface of seborreic keratosis, Bowen's disease, and squamous cell carcinoma as in normal skin, we could not detect any CD44 expression on the cell surface of the tumor cells of basal cell carcinoma. However, CD44 positive dendritic cells were observed in the tumor islands of basal cell carcinoma. Phenotypic analysis suggested that these CD44 positive cells were melanocytes.
References
Sep 1, 1992·Journal of the American Academy of Dermatology·M FurueK Sagawa
Sep 1, 1992·Histochemistry·C WangR Tammi
Jun 29, 1990·Cell·A AruffoB Seed
Apr 5, 1991·Cell·U GünthertP Herrlich
Dec 1, 1991·The Journal of Cell Biology·R L CampE Puré
Apr 1, 1991·The Journal of Cell Biology·T A BrownW G Carter
Jul 1, 1990·The Journal of Investigative Dermatology·K Weber-Matthiesen, W Sterry
Feb 1, 1987·Journal of Immunogenetics·V R SuttonI F McKenzie
Mar 1, 1988·The Journal of Investigative Dermatology·R TammiM Tammi
Apr 1, 1989·The Journal of Cell Biology·A M Alho, C B Underhill
Nov 1, 1967·Archives of Dermatology·A S Zelickson
Nov 5, 1981·Nature·D CocchiaR Donato
Apr 1, 1993·The Journal of Investigative Dermatology·I BruynzeelR Willemze
Feb 1, 1993·The Journal of Investigative Dermatology·L ThomasH R Byers
Citations
Jan 1, 1997·Journal of Cutaneous Pathology·A DietrichJ C Simon
Apr 24, 1999·The British Journal of Dermatology·K P DingemansS T Pals
Mar 19, 2015·Advances in Wound Care·Margaret Mary Smith, James Melrose
Apr 7, 2012·Human Gene Therapy·Maria Fernanda LaraRoger L Kaspar
Apr 29, 1998·Journal of Cutaneous Pathology·P E SwansonM R Wick
Aug 1, 1996·International Journal of Dermatology·W Manuskiatti, H I Maibach
Apr 30, 2013·Oncogene·P TripathiF Chen
Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·W K SeelentagJ Roth
Aug 19, 2000·Endocrine Reviews·D Deplewski, R L Rosenfield
Jan 22, 2003·The British Journal of Dermatology·S KarvinenR Tammi
Mar 28, 2019·Journal of Biomedical Materials Research. Part a·Marie SchneiderVuk Savkovic