CD44 in cancer progression: adhesion, migration and growth regulation

Journal of Molecular Histology
R Marhaba, M Zöller

Abstract

It is well established that the large array of functions that a tumour cell has to fulfil to settle as a metastasis in a distant organ requires cooperative activities between the tumour and the surrounding tissue and that several classes of molecules are involved, such as cell-cell and cell-matrix adhesion molecules and matrix degrading enzymes, to name only a few. Furthermore, metastasis formation requires concerted activities between tumour cells and surrounding cells as well as matrix elements and possibly concerted activities between individual molecules of the tumour cell itself. Adhesion molecules have originally been thought to be essential for the formation of multicellular organisms and to tether cells to the extracellular matrix or to neighbouring cells. CD44 transmembrane glycoproteins belong to the families of adhesion molecules and have originally been described to mediate lymphocyte homing to peripheral lymphoid tissues. It was soon recognized that the molecules, under selective conditions, may suffice to initiate metastatic spread of tumour cells. The question remained as to how a single adhesion molecule can fulfil that task. This review outlines that adhesion is by no means a passive task. Rather, ligand bindin...Continue Reading

Citations

Jan 10, 2012·Clinical & Experimental Metastasis·Hidenori OzakiHisashi Narimatsu
Nov 28, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jeroen F VermeulenPatrick W B Derksen
Jan 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Xiao-Feng LeGeorge A Calin
Sep 22, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cuizhen LiAndrew H Fischer
Nov 17, 2010·The Journal of Biological Chemistry·Daniel HernándezAnna Bassols
Mar 5, 2011·The Journal of Biological Chemistry·Thorsten JungMargot Zöller
Mar 20, 2010·Lymphatic Research and Biology·Angelo M Taveira-DaSilvaJoel Moss
Oct 22, 2010·Molecular Biology of the Cell·Ester Martín-VillarMiguel Quintanilla
Oct 29, 2005·Journal of Clinical Pathology·G M K TseB K B Law
May 21, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Phil-Sun OhAdhip P N Majumdar
Aug 19, 2010·Molecular Cancer Therapeutics·Stephen B Keysar, Antonio Jimeno
Jul 20, 2010·American Journal of Respiratory and Critical Care Medicine·Xiong CaiJoel Moss
Jan 16, 2007·BMC Cancer·Giuseppe SarliCinzia Benazzi
Mar 18, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Heike ImmervollAnders Molven
Nov 16, 2012·Biologics : Targets & Therapy·Serena Trapasso, Eugenia Allegra
Dec 7, 2007·American Journal of Veterinary Research·María-José DocampoAnna Bassols
Nov 15, 2008·World Journal of Gastroenterology : WJG·Kamran GhaffarzadehganMaryam Bahrani
Aug 2, 2011·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Juhua ZhouMitzi Nagarkatti
Oct 15, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·D SpiegelbergM Nestor
Dec 2, 2015·Acta Biochimica Et Biophysica Sinica·Kaiyuan DengJiazeng Xia
May 11, 2010·Journal of Biomedicine & Biotechnology·Céline PinheiroFátima Baltazar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Molecular Pathology : MP
S GoodisonD Tarin
Nature Reviews. Molecular Cell Biology
H PontaP Herrlich
Proceedings of the National Academy of Sciences of the United States of America
Muhammad Al-HajjMichael F Clarke
© 2021 Meta ULC. All rights reserved