CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.

Blood
Niklas MuellerPeter Valent

Abstract

The Hermes receptor CD44 is a multifunctional adhesion molecule that plays an essential role in the homing and invasion of neoplastic stem cells in various myeloid malignancies. Although mast cells (MCs) reportedly express CD44, little is known about the regulation and function of this receptor in neoplastic cells in systemic mastocytosis (SM). We found that clonal CD34+/CD38- stem cells, CD34+/CD38+ progenitor cells, and CD117++/CD34- MCs invariably express CD44 in patients with indolent SM (ISM), SM with an associated hematologic neoplasm, aggressive SM, and MC leukemia (MCL). In addition, all human MCL-like cell lines examined (HMC-1, ROSA, and MCPV-1) displayed cytoplasmic and cell-surface CD44. We also found that expression of CD44 in neoplastic MCs depends on RAS-MEK and STAT5 signaling and increases with the aggressiveness of SM. Correspondingly, higher levels of soluble CD44 were measured in the sera of patients with advanced SM compared with ISM or cutaneous mastocytosis and were found to correlate with overall and progression-free survival. To investigate the functional role of CD44, a xenotransplantation model was employed using severe combined immunodeficient (SCID) mice, HMC-1.2 cells, and a short hairpin RNA (shRN...Continue Reading

References

Feb 27, 1992·The New England Journal of Medicine·K F Austen
Jan 1, 1990·International Archives of Allergy and Applied Immunology·P ValentP Bettelheim
Dec 1, 1986·Mayo Clinic Proceedings·W D TravisP M Banks
Jan 1, 1988·Leukemia Research·J H ButterfieldG J Gleich
Oct 1, 1996·Virchows Archiv : an International Journal of Pathology·H P HornyE Kaiserling
Nov 14, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T LapidotO Kollet
Feb 29, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M FukuiJ Dastych
Mar 1, 2000·Molecular Pathology : MP·S GoodisonD Tarin
Mar 22, 2000·Hematological Oncology·A YokotaK Harigaya
May 30, 2001·Leukemia Research·P ValentJ M Bennett
Jul 27, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·N TaçyildizS Cin
Mar 29, 2002·International Archives of Allergy and Immunology·Karin Hartmann, Beate M Henz
May 1, 1996·Wilderness & Environmental Medicine·P S Hodgson, T M Davidson
May 10, 2002·The American Journal of Pathology·Friedrich WimazalPeter Valent
May 22, 2002·International Archives of Allergy and Immunology·Minoo GhannadanPeter Valent
Dec 17, 2002·Annals of Hematology·L EscribanoD D Metcalfe
Dec 18, 2002·Critical Reviews in Clinical Laboratory Sciences·David NaorYoram Faitelson
Jan 30, 2004·Annual Review of Medicine·Cem Akin, Dean D Metcalfe
Nov 6, 2004·Blood·Lucy J ElrickTessa L Holyoake
Sep 24, 2005·International Archives of Allergy and Immunology·Maria-Theresa KrauthPeter Valent
Feb 25, 2006·Cell Death and Differentiation·T BraunG Kroemer
Sep 26, 2006·Nature Medicine·Daniela S KrauseRichard A Van Etten
Sep 26, 2006·Nature Medicine·Liqing JinJohn E Dick
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bernard M TijinkGuus A M S van Dongen
Mar 1, 2008·British Journal of Haematology·Gandhi DamajOlivier Hermine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.