CD44 mediates constitutive type I receptor signaling in cervical carcinoma cells

Gynecologic Oncology
M WobusLarry S Sherman

Abstract

The CD44 transmembrane glycoprotein family has been implicated in the growth and metastasis of numerous human cancers. CD44 may function in some cells through interactions with type I receptor tyrosine kinases, including erbB2. Here, we tested whether CD44 interacts with erbB2 and another type I receptor, the epidermal growth factor receptor (EGFR), in human cervical carcinoma tissues and cell lines and whether these interactions influence erbB2 signaling. CD44, EGFR, and erbB2 colocalization were examined in 36 pT1b-pT2b cervical cancer cases and in the CaSki and SiHa cervical carcinoma cell lines by immunohistochemistry and laser scanning confocal microscopy. The role of CD44-EGFR-erbB2 interactions in erbB2 signaling was examined by immunoprecipitation and using antisense CD44 oligonucleotides. CD44, erbB2, and EGFR coexpression and colocalization were observed in 42% (15/36) of cervical carcinoma cases and in both cervical carcinoma cell lines. Colocalization occurred to an equivalent extent in all tumor grades examined. CD44 coimmunoprecipitated with erbB2 and EGFR in cervical carcinoma cell lysates, indicating that these proteins interact with each other. Reduction of CD44 expression inhibited constitutive erbB2 activity....Continue Reading

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Citations

Dec 24, 2008·Molecular and Cellular Biology·S Sean HoushmandiDavid H Gutmann
Sep 2, 2008·American Journal of Respiratory Cell and Molecular Biology·S Marina Casalino-MatsudaRosanna M Forteza
Jul 12, 2005·Archives of Gynecology and Obstetrics·L-C HornR Martin
Mar 2, 2011·The American Journal of Pathology·Steven J Wang, Lilly Y W Bourguignon
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Mar 8, 2014·Molecular Medicine Reports·Songshu XiaoMin Xue
Jun 17, 2014·Oncology Letters·Songshu XiaoMin Xue
Jun 13, 2019·Oncology Letters·Daranee ChokchaichamnankitChantragan Srisomsap
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Manja WobusLarry S Sherman

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