CD44 targeted PLGA nanomedicines for cancer chemotherapy

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Ankit SanejaPrem N Gupta

Abstract

In recent years scientific community has drawn a great deal of attention towards understanding the enigma of cluster of differentiation-44 (CD44) in order to deliver therapeutic agents more selectively towards tumor tissues. Moreover, its over-expression in variety of solid tumors has attracted drug delivery researchers to target this receptor with nanomedicines. Conventional nanomedicines based on biodegradable polymers such as poly(lactide-co-glycolide) (PLGA) are often associated with insufficient cellular uptake by cancer cells, due to lack of active targeting moiety on their surface. Therefore, to address this limitation, CD44 targeted PLGA nanomedicines has gained considerable interest for enhancing the efficacy of chemotherapeutic agents. In this review, we have elaborately discussed the recent progress in the design and synthesis of CD44 targeted PLGA nanomedicines used to improve tumor-targeted drug delivery. We have also discussed strategies based on co-targeting of CD44 with other targeting moieties such as folic acid, human epidermal growth factor 2 (HER2), monoclonal antibodies using PLGA based nanomedicines.

Citations

Sep 17, 2020·International Journal of Molecular Sciences·Sergey SedykhGeorgy Nevinsky
Sep 24, 2020·American Journal of Reproductive Immunology : AJRI·Raghuram KandimallaRamesh Gupta
Oct 7, 2019·Drug Discovery Today·Mohammad NorouziFatemeh Atyabi
Dec 12, 2020·Experimental Hematology & Oncology·Hanxiao XuAiguo Liu
Apr 21, 2019·International Journal of Biological Macromolecules·Robin KumarAmulya K Panda
Nov 6, 2020·International Journal of Pharmaceutics·Shweta ParohaPrashant Kesharwani

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