Abstract
The change in the expression pattern of CD44 variant 6 (CD44v6) protein in benign, premalignant, and malignant (SCC) oral epithelial lesions was studied immunohistochemically and compared with the pattern in normal mucosa in order to examine whether this gene can serve as a progression marker in patients with SCC. The principal findings is that CD44v6 expression was clearly downregulated in most cases of severe premalignant lesions as well as in most of the SCCs. The staining pattern and intensity varied according to the degree of dysplasia and to the degree of differentiation of the SCCs. Premalignant severe epithelial dysplasia cases with early features of invasion, not yet developed into SCC, showed distinctly downregulated expression of CD44v6 protein whereas hyperplastic and benign epithelial lesions (papilloma) expressed positive staining patterns comparable to those of the normal counterparts. The authors conclude that alteration in CD44v6 may occur as an early event in primary oral SCC development, as well as in premalignant severe epithelial dysplasia. It can thus, be used as a molecular progression marker when screening for oral cancer.
References
Oct 31, 1992·Lancet·Y Matsumura, D Tarin
Jun 29, 1990·Cell·A AruffoB Seed
Dec 1, 1990·The Journal of Cell Biology·M CultyE Silorski
Apr 5, 1991·Cell·U GünthertP Herrlich
Apr 1, 1990·Experimental Cell Research·J LesleyR Hyman
Jul 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Mar 24, 1989·Cell·L A GoldsteinE C Butcher
Jan 1, 1994·The Journal of Cell Biology·C R MackayU Günthert
Mar 1, 1994·Cancer Research·M B PennoC Rosada
Aug 28, 1993·Lancet·S B FoxJ Fawcett
Jul 1, 1993·The Journal of Cell Biology·M SalmiS Jalkanen
Jan 1, 1993·The Journal of Cell Biology·K H HeiderS T Pals
Aug 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J DämmrichH K Müller-Hermelink
Oct 1, 1995·Journal of Cutaneous Pathology·S N DommannG Burg
Jun 1, 1996·Archives of Otolaryngology--head & Neck Surgery·M F SpaffordW A Franklin
May 24, 1996·Biochemical and Biophysical Research Communications·S FrankG Schackert
Jul 15, 1996·Cancer·C TempferC Kainz
Aug 1, 1997·International Journal of Oral and Maxillofacial Surgery·M KunishiK Yoshiga
Citations
Nov 13, 2012·Head and Neck Pathology·Sarah G FitzpatrickIndraneel Bhattacharyya
Jan 30, 2004·Oral Oncology·Miguel Angel González-MolesSalvador González-Moles
Apr 5, 2003·Oral Oncology·Jaana RautavaKristiina Heikinheimo
Jan 14, 2012·PloS One·Abirami RajarajanEdward W Odell
Nov 29, 2012·OncoTargets and Therapy·Eugenia Allegra, Serena Trapasso
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Kn HemaHs Sheethal
Oct 11, 2002·The Journal of Pathology·Agnes BánkfalviJozsef Piffkó
May 11, 2000·Japanese Journal of Cancer Research : Gann·M KankeY Matsumura
Jun 27, 2006·Oral Oncology·A KosunenV-M Kosma
Mar 29, 2005·Oral Oncology·Francesco CarinciFurio Pezzetti
Jan 6, 2000·Gynecologic Oncology·G CallagyE Kay
Jul 16, 2003·Journal of Zhejiang University. Science·Ya-Ping XuP Moubayed
Apr 14, 2010·Expert Opinion on Investigational Drugs·Sen YangLouis W C Chow
Nov 2, 2013·Biomarkers in Cancer·Ahmad A Abdulmajeed, Camile S Farah
Jul 29, 2000·Leukemia·L J BendallD J Gottlieb
Sep 14, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·Sashi Kiran Sanapala Venkat NagaBaddam Venkat Ramana Reddy
Oct 24, 2001·In Vitro Cellular & Developmental Biology. Animal·E R SalterA M Herlyn