PMID: 9418147Jan 7, 1998Paper

CD44 variant 6 (CD44v6) expression as a progression marker in benign, premalignant and malignant oral epithelial tissues

International Journal of Oral and Maxillofacial Surgery
R BaharK Yoshiga

Abstract

The change in the expression pattern of CD44 variant 6 (CD44v6) protein in benign, premalignant, and malignant (SCC) oral epithelial lesions was studied immunohistochemically and compared with the pattern in normal mucosa in order to examine whether this gene can serve as a progression marker in patients with SCC. The principal findings is that CD44v6 expression was clearly downregulated in most cases of severe premalignant lesions as well as in most of the SCCs. The staining pattern and intensity varied according to the degree of dysplasia and to the degree of differentiation of the SCCs. Premalignant severe epithelial dysplasia cases with early features of invasion, not yet developed into SCC, showed distinctly downregulated expression of CD44v6 protein whereas hyperplastic and benign epithelial lesions (papilloma) expressed positive staining patterns comparable to those of the normal counterparts. The authors conclude that alteration in CD44v6 may occur as an early event in primary oral SCC development, as well as in premalignant severe epithelial dysplasia. It can thus, be used as a molecular progression marker when screening for oral cancer.

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Citations

Nov 13, 2012·Head and Neck Pathology·Sarah G FitzpatrickIndraneel Bhattacharyya
Jan 30, 2004·Oral Oncology·Miguel Angel González-MolesSalvador González-Moles
Apr 5, 2003·Oral Oncology·Jaana RautavaKristiina Heikinheimo
Jan 14, 2012·PloS One·Abirami RajarajanEdward W Odell
Nov 29, 2012·OncoTargets and Therapy·Eugenia Allegra, Serena Trapasso
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Kn HemaHs Sheethal
May 11, 2000·Japanese Journal of Cancer Research : Gann·M KankeY Matsumura
Mar 29, 2005·Oral Oncology·Francesco CarinciFurio Pezzetti
Apr 14, 2010·Expert Opinion on Investigational Drugs·Sen YangLouis W C Chow
Sep 14, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·Sashi Kiran Sanapala Venkat NagaBaddam Venkat Ramana Reddy
Oct 24, 2001·In Vitro Cellular & Developmental Biology. Animal·E R SalterA M Herlyn

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