CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Se-Il GoWoo Song Ha

Abstract

The present study is to investigate the significance of CD44 variant 9 (CD44v9) expression as a biomarker in primary gastric cancer. With various gastric tissues, we performed immunohistochemical staining for CD44v9. The positive expression rates for CD44v9 in tumor, including adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC), were higher than those in non-tumor tissues (p=0.003). In addition, the higher expression for CD44v9 was observed as the tissue becomes malignant. In the analysis of 333 gastric cancer tissues, we found that positive expression rates for CD44v9 were higher in the intestinal type or well differentiated gastric cancer than in the diffuse type or poorly differentiated gastric cancer. Interestingly, the positive expression indicated poor prognosis in EGC (5-year survival rate [5-YSR] in stage I, 81.7% vs. 95.2%; p=0.013), but not in AGC (5-YSR in stage II, 66.9% vs. 62.2%; p=0.821; 5-YSR in stage III, 34.5% vs. 32.0%; p=0.929). Moreover, strong positive expression (3+) showed a trend suggesting worse prognosis only in EGC, and it appeared to be associated with lymph node metastasis. This study suggests that CD44v9 may be a good biomarker for prognosis prediction and for chemoprevention or...Continue Reading

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Citations

Oct 3, 2015·Journal of Gastroenterology·Daniel BrungsMarie Ranson
Apr 9, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kohei ShitaraAtsushi Ohtsu
Oct 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fatemeh B RassouliMorvarid Saeinasab
Aug 19, 2016·Journal of Cancer Research and Clinical Oncology·Ruo-Lin WuXiao-Ping Geng
Feb 24, 2018·Japanese Journal of Clinical Oncology·Noriko HiyamaDaiya Takai
May 21, 2020·The Journal of Pathology·Katherine M RieraJames R Goldenring
May 4, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kohei ShitaraAtsushi Ohtsu
Mar 28, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Se-Il GoWoo Song Ha
Aug 23, 2020·International Journal of Molecular Sciences·Jinfen WeiHongli Du
Dec 21, 2019·Cancer Cell International·Wei-Zhao PengJian-Zheng Jie
Sep 2, 2019·Cellular and Molecular Gastroenterology and Hepatology·Takahiro ShimizuJames R Goldenring
Aug 5, 2019·Molecular Aspects of Medicine·Luis Enrique Cortés-HernándezCatherine Alix-Panabières
May 31, 2019·Cellular and Molecular Gastroenterology and Hepatology·Hitoshi TsugawaHidekazu Suzuki
May 9, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tomoko JogoMasaki Mori
Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Mohammad Mahmoudi GomariParastoo Tarighi
Sep 2, 2021·Saudi Journal of Biological Sciences·C R AkshathaShashanka K Prasad

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Methods Mentioned

BETA
dissection
biopsies

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