CD44s and CD44v6 in diagnosis and prognosis of human bladder cancer

Ultrastructural Pathology
Ola M Omran, Hesham S Ata

Abstract

The cell adhesion molecules (CAMs) CD44 standard (CD44s) and its variant 6 (CD44v6) are involved in the progression and invasion of human malignancies. However, discrepancies in the prognostic value of CD44s and CD44v6 expression need to be addressed. To investigate the expression of CD44s and CD44v6 in bladder carcinomas and relate the results to the established prognostic factors. 50 bladder carcinoma specimens, 30 cases with transitional cell carcinoma (TCC: 6 bilharzial and 24 nonbilharzial) and 20 cases with squamous cell carcinoma (SCC: 8 bilharzial and 12 nonbilharzial), were included. Immunohistochemical analysis for CD44s and CD44v6 was carried out using avidin-biotin peroxidase method. The level of both CD44s and CD44v6 in TCC was significantly higher in invasive than in preinvasive tumors and normal urothelium (p < .05). A direct association between the percentage of expression of both markers and the grade of TCC (p < .05) was observed. An inverse correlation between CD44s and SCC was seen, where metaplastic urothelium showed higher expression than invasive carcinomas. No association was observed between the expressions of both CD44s and CD44v6 and bilharzial ova, sex and age of the patient, or size of the tumor. Th...Continue Reading

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Citations

May 4, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Bernd BürkleGünther A Rezniczek
Jul 15, 2015·Cancer Epidemiology·Nut KoonrungsesomboonEvaristus Chibunna Mbanefo
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Jan 6, 2021·Molecular Biology Reports·Debanwita Roy BurmanRahul Bhattacharya

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