CD44v10 expression in the mouse and functional activity in delayed type hypersensitivity

Journal of Cellular Physiology
M RöselM Zöller

Abstract

We have described recently that expression of CD44 exon v10 (CD44v10) is down-regulated upon metastasis of squamous cell carcinoma, whereas it is up-regulated in skin metastases of malignant melanoma. The striking regulation of CD44v10 prompted us to generate a murine CD44v10-specific monoclonal antibody to define expression and possible functions of this particular CD44 variant isoform. In the mouse, expression of exon v10 was restricted to basal layers of the epidermis and squamous epithelium of the oral cavity, the esophagus, the omasum, glandular epithelium of the submandibular and the uterine gland, as well as subpopulations of bone marrow cells and activated lymphocytes. Expression started late during development, e.g., was not observed before day 16 of gestation and there was no evidence for developmental regulation of CD44v10 expression. Functional in vivo studies revealed that anti-CD44v10 had no effect on wound healing but inhibited edema and granuloma formation in delayed type hypersensitivity (DTH). Furthermore, lymphocyte-monocyte interactions could be inhibited by anti-CD44v10. Because a CD44v10 transfected tumour line did not show any distinct pattern of cell-matrix or cell-cell adhesion, the data point toward an...Continue Reading

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Citations

Apr 21, 1999·Experimental Hematology·M RöselM Zöller
Apr 12, 2001·International Journal of Experimental Pathology·A O'Regan, J S Berman
Dec 10, 2002·Hybridoma and Hybridomics·S M DavernS J Kennel
Oct 2, 1998·Tissue Antigens·M RöselM Zöller
Jun 18, 2014·Immunology and Cell Biology·Amelie Pajip MegaptcheMargot Zöller
Nov 22, 2005·The Journal of Investigative Dermatology·Pia Freyschmidt-PaulMargot Zöller
May 6, 2006·The Journal of Investigative Dermatology·Pooja GuptaMargot Zöller
Sep 21, 2000·The Journal of Investigative Dermatology·P Freyschmidt-PaulR Hoffmann
Mar 11, 2004·Clinical and Experimental Immunology·M ZöllerR Hoffmann
May 28, 2009·Experimental Dermatology·Mona ManMao-Qiang Man
Oct 3, 1998·Clinical Immunology and Immunopathology·S SeiterM Zöller
Oct 10, 2001·European Journal of Immunology·C SchwärzlerU Günthert
Mar 20, 1998·International Journal of Cancer. Journal International Du Cancer·V ZawadzkiM Zöller
Nov 9, 2000·European Journal of Immunology·N FögerM Zöller
Sep 18, 1998·The Journal of Investigative Dermatology·S N WagnerM Goos
May 17, 2005·Cellular Signalling·Rachid MarhabaMargot Zöller

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