Dec 12, 2017

CD44V6 regulates gastric carcinoma occurrence and development through up-regulating VEGF expression

European Review for Medical and Pharmacological Sciences
S LiangJ-H Cui


Gastric carcinoma (GC) is one of the most common malignant tumors around the world. It is featured as high morbidity, poor prognosis, and short survival, thus seriously threats to the quality of life. The mechanism of GC is still unclear, leading to a difficulty in the treatment. CD44V6 plays an important role in tumorigenesis and progression, while its role in GC still needs further elucidation. GC tissue and para-carcinoma tissue were collected from patients in different tumor-mode-metastasis (TNM) stages. CD44V6 and vascular endothelial growth factor (VEGF) expressions were detected by real-time PCR and Western blot. Their correlations with the clinicopathological characteristics of GC were analyzed. GC cell line SGC-7901 was cultured in vitro and divided into control, scramble group, and CD44V6 small interfering RNA (siRNA) group. Cell proliferation was assessed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. Cell apoptosis was evaluated by caspase 3 activity assay. CD44V6 and VEGF protein expressions significantly increased in GC tissue compared with adjacent normal control (p < 0.05). CD44V6 expression was correlated with differentiation, lymph node metastasis, and TNM staging (p < 0.05)....Continue Reading

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Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Morbidity Aspects
Oculodigitoesophagoduodenal Syndrome
TNM Staging System
Malignant Neoplasm of Stomach
Stomach Carcinoma
RNA, Small Interfering
Glioma-Derived Vascular Endothelial Cell Growth Factor

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