CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity

Scientific Reports
Hasiyeti MaimaitiyimingShuxia Wang

Abstract

CD47 is a transmembrane protein with several functions including self-recognition, immune cell communication, and cell signaling. Although it has been extensively studied in cancer and ischemia, CD47 function in obesity has never been explored. In this study, we utilized CD47 deficient mice in a high-fat diet induced obesity model to study for the first time whether CD47 plays a role in the development of obesity and metabolic complications. Male CD47 deficient and wild type (WT) control mice were fed with either low fat (LF) or high fat (HF) diets for 16 weeks. Interestingly, we found that CD47 deficient mice were protected from HF diet-induced obesity displaying decreased weight gain and reduced adiposity. This led to decreased MCP1/CCR2 dependent macrophage infiltration into adipose tissue and reduced inflammation, resulting in improved glucose tolerance and insulin sensitivity. In addition, CD47 deficiency stimulated the expression of UCP1 and carnitine palmitoyltransferase 1b (CPT1b) levels in brown adipose tissue, leading to increased lipid utilization and heat production. This contributes to the increased energy utilization and reduced adiposity observed in these mice. Taken together, these data revealed a novel role for...Continue Reading

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Citations

Jun 5, 2020·Scandinavian Journal of Gastroenterology·Lei FengHeng Du
May 7, 2020·American Journal of Physiology. Cell Physiology·Jeffrey S Isenberg, David D Roberts
Dec 18, 2020·Biology Open·Heather Norman-BurgdolfShuxia Wang
May 1, 2021·International Journal of Molecular Sciences·Atharva KaleKedar Ghimire
Jun 10, 2021·American Journal of Physiology. Cell Physiology·David D Roberts, Jeffrey S Isenberg
Aug 29, 2021·Biochemical and Biophysical Research Communications·Dong LiShuxia Wang

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

MyiQ system
Quantity One gel Analysis
- Elements BR

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