CD4+CD25+ lymphocyte subsets in chronic graft versus host disease patients undergoing extracorporeal photochemotherapy

International Journal of Immunopathology and Pharmacology
P RubegniM Fimiani

Abstract

Extracorporeal photochemotherapy (ECP) has been used successfully for the treatment of chronic Graft versus Host Disease (cGvHD). However, the mechanism by which ECP exerts its protective effects remains elusive. Some recent observations have suggested a possible role of certain subsets of T lymphocytes with immunosuppressive properties (T-regulatory cells) that coexpress CD4 and high levels of the interleukin-2 receptor chain: CD4+CD25+ T lymphocytes. We studied whether ECP affects the percentage of these cells in the peripheral blood of patients with cGvHD. The study population consisted of 14 patients with cGvHD refractory to systemic steroids. On enrollment in each cycle of ECP, patients underwent clinical examination, blood chemistry analysis and other instrumental procedures to document and assess involvement of the various organs and systems. For cytofluorimetric identification and phenotyping of CD4+CD25+ T lymphocytes, peripheral blood samples were collected in EDTA anticoagulant before ECP, after 48 hours, and after 6 and 12 months from the start of treatment. The 14 patients in this study received a total of more than 300 cycles of ECP, with only minor side effects. The clinical outcome was negative in 2 patients and...Continue Reading

References

Jun 1, 2002·Bone Marrow Transplantation·F M FossK B Miller
Aug 7, 2002·The Journal of Experimental Medicine·José L CohenBenoît L Salomon
Aug 8, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·R Dall'Amico, C Messina
May 20, 2003·Immunological Reviews·Thomas A FergusonThomas S Griffith
Jun 25, 2004·The British Journal of Dermatology·M FimianiP Rubegni
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira MaedaThomas Schwarz
Jan 24, 2006·Blood Reviews·Mitchell E Horwitz, Keith M Sullivan

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Citations

Jul 1, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Pablo Augusto Vieyra-Garcia, Peter Wolf

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