CD4(+)CD25(+) regulatory T cells resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Nagendra SinghMakio Iwashima

Abstract

Ag receptor stimulation of preactivated T cells causes rapid cell death in an IL-2- and Fas-dependent manner. This phenomenon, known as activation-induced cell death (AICD), plays a pivotal role in the removal of Ag-reactive T cells after initial expansion. In this study, we report a novel form of T cell apoptosis that is distinct from classic AICD. When peripheral T cells were activated with anti-CD3 and anti-CD28 Abs precoated onto plastic plates, CD4(+)CD25(-) and CD8 T cells initially expanded but underwent massive apoptosis after 4 d. Unlike classic AICD, this type of T cell apoptosis pathway requires engagement of CD28 and expression of p53, a tumor-suppressor gene. The most striking feature of this form of apoptosis was regulatory T cell resistance. Under the same stimulating conditions, CD4(+)CD25(+) T cells grew continuously beyond 4 d. Consequently, when the entire CD4 population was cultured with plate-bound anti-CD3 plus anti-CD28 Ab, CD4(+)CD25(+)FoxP3(+) regulatory T cells outgrew nonregulatory T cells and expanded >7000-fold after 11 d. The data presented herein demonstrate a novel process of Ag-induced T cell death by sustained TCR and CD28 engagement and represent a simple and efficient procedure for the expans...Continue Reading

References

Oct 1, 1992·The Journal of Experimental Medicine·N K BandaT H Finkel
Jun 1, 1995·Molecular and Cellular Biology·L B Owen-SchaubE Kruzel
Apr 1, 1996·The Journal of Experimental Medicine·G Süss, K Shortman
Dec 1, 1996·European Journal of Immunology·D E SpeiserP S Ohashi
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·P Scheipers, H Reiser
May 10, 2000·Current Biology : CB·T Caspari
Dec 1, 2000·Nature·B VogelsteinA J Levine
Mar 13, 2001·Annual Review of Immunology·B Salomon, J A Bluestone
Nov 20, 2001·Nature Immunology·S K BromleyM L Dustin
Apr 24, 2002·Immunity·Jesus M SalvadorAlbert J Fornace
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott A WetzelDavid C Parker
Feb 11, 2003·Journal of Neuroimmunology·Yoshinobu OkudaClaude C A Bernard
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian ZhangAlison Finnegan
May 20, 2003·Immunological Reviews·Douglas R GreenMichael Pinkoski
Jan 10, 2004·Immunologic Research·Shi-Jun Zheng, Youhai H Chen
Jan 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dan Chen, Qiang Zhou
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Elena SandalovaVictor Levitsky
Jun 9, 2004·The Journal of Experimental Medicine·Qizhi TangJeffrey A Bluestone
Jan 22, 2005·Immunological Reviews·Hans D OchsTroy R Torgerson
Jun 4, 2005·Arthritis and Rheumatism·Egle SimelyteGary S Firestein
Sep 24, 2005·Annals of Neurology·Xinqing DengSubramaniam Sriram
Nov 17, 2005·The Journal of Experimental Medicine·Lin LiuBinfeng Lu
Feb 4, 2006·Molecular Cell·Christopher L Brooks, Wei Gu
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristina F AriasDimitrios Balomenos
Jun 26, 2007·Nature Reviews. Immunology·Peter H KrammerInna N Lavrik
Nov 23, 2007·Nature·Lauren W CollisonDario A A Vignali
Apr 9, 2008·European Journal of Immunology·Yasmine Belkaid
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jul 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OnishiShimon Sakaguchi

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Citations

Apr 24, 2012·Cellular & Molecular Immunology·Daniel SilbermanJames E Riggs
Jun 16, 2012·PloS One·Shivanee ShahMakio Iwashima
Oct 29, 2011·Molecular Medicine·Matthew W Klinker, Steven K Lundy
Mar 8, 2013·Future Medicinal Chemistry·Makio Iwashima, Robert Love
Nov 30, 2016·International Journal of Molecular Sciences·Alessandra Fierabracci, Marsha Pellegrino
Sep 21, 2020·The Australasian Journal of Dermatology·Radwa El-Sayed Mahmoud MarieLina M Atef
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariko TakamiMakio Iwashima
Sep 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hirotoshi KawashimaHiroshi Nakajima
Nov 1, 2016·Nature Reviews. Immunology·César Muñoz-FontelaSam W Lee
Jul 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva-Maria WeissPeter H Krammer
Feb 13, 2020·NPJ Vaccines·Ashley L St JohnHerman F Staats
Feb 5, 2021·NPJ Vaccines·Ashley L St JohnHerman F Staats

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