CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor

BMC Immunology
Raquel Matavele ChissumbaWilson Savino

Abstract

Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-infection are more prone to develop neurological complications. The aim of this study was to characterize phenotypically Treg cells in HIV-1/HTLV-1 co-infected Mozambican individuals presenting neurological symptoms. A cross-sectional study was conducted among HIV-infected individuals presentingneurological symptoms, with and without HTLV co-infection, and blood donors. Peripheral bloodmononuclear cells were stained with monoclonal antibodies conjugated with fluorochromes to quantifyTregs and activated T cells by four colors flow cytometry. Higher Treg cell frequency (10.6%) was noted in HIV-1/HTLV-1 co-infected group with neurological symptoms when compared to HIV-1 mono-infected group with neurological symptoms (0.38%, p = 0.003) and control group (0.9%, p = 0.0105). An inverse correlation between Foxp3 and CD49d expression was observed in all study groups (rh = -0.71, p = 0.001). In addition, increased levels of Treg cells...Continue Reading

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Citations

Jan 9, 2016·PLoS Neglected Tropical Diseases·Florencia Belén GonzálezAna Rosa Pérez
Jun 13, 2017·Frontiers in Immunology·Leonn Mendes Soares PereiraAntonio Carlos Rosário Vallinoto

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Methods Mentioned

BETA
Enzyme-Linked ImmunoSorbent Assay

Software Mentioned

CellQuest
GraphPad Prism
GraphPad
MULTISET [UNK]
STATA

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