PMID: 15371918Sep 17, 2004Paper

CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease

European Journal of Gastroenterology & Hepatology
J CartonC O'Farrelly

Abstract

The intestinal lesion of coeliac disease is thought to be initiated and exacerbated by dysregulation of local T-lymphocyte sub-populations. This study examines changes in intestinal T cells from coeliac patients, with a particular focus on CD4CD8 T cells, immunoregulatory cells normally found in relatively high proportions in the small intestine. Cells were obtained from duodenal biopsies from active and treated coeliac patients using chelating and reducing agents (epithelial layer) followed by collagenase treatment (lamina propria). Cell yield and viability were assessed and flow cytometric analysis was used to examine CD4CD8 T cells and to quantify CD8 expression. Surprisingly, total T-cell yields in the epithelial layer did not increase in active coeliac disease although enterocyte counts decreased significantly, giving an appearance of infiltration. In active coeliac patients, CD4CD8 T cell percentages were significantly decreased in both the epithelial layer and lamina propria. Levels of CD8 expression by CD4CD8 T cells in the epithelial layer were decreased significantly in patients with active coeliac disease. CD4CD8 T cell proportions did not return to normal in treated coeliac patients whose villous architecture had re...Continue Reading

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Citations

Jan 20, 2009·Current HIV/AIDS Reports·Paul W Denton, J Victor Garcia
Mar 29, 2007·The Journal of Experimental Medicine·Zhifeng SunJ Victor Garcia
May 29, 2007·AIDS Research and Human Retroviruses·Kristina E Howard, Mary Jo Burkhard
Jul 12, 2013·PloS One·Luc Van KaerDanyvid Olivares-Villagómez
Jun 22, 2014·Journal of Immunological Methods·Angela Wahl, J Victor Garcia
Sep 14, 2010·Journal of Immunological Methods·Francisco Leon
Jul 23, 2016·Current Opinion in Virology·J Victor Garcia
Oct 5, 2007·International Journal of Surgical Pathology·Ricardo Drut, Eduardo Cueto Rúa
Sep 17, 2004·European Journal of Gastroenterology & Hepatology·R G Peter Watson, Simon D Johnston
Aug 28, 2019·Immunological Medicine·Hayakazu Sumida
Mar 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luc Van Kaer, Danyvid Olivares-Villagómez
Mar 13, 2019·Nature Reviews. Immunology·Ashwin N SkellyKenya Honda
Jan 28, 2021·European Journal of Immunology·Veronika NiederlovaOndrej Stepanek

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