CD5 as a Target for Immune-Based Therapies

Critical Reviews in Immunology
Marta Consuegra-FernándezFrancisco Lozano

Abstract

CD5 was one of the first surface receptors described for mouse and human T lymphocytes. Since then, it has been found to be highly expressed by regulatory T cells and a subpopulation of regulatory B cells, to be physically associated with the T- and B-cell antigen receptors, to negatively modulate TCR- and BCR-mediated signals, and to bind certain pathogen-associated molecular patterns. These findings position CD5 as an attractive target for developing immunotherapies aimed at either boosting or dampening ongoing immune responses. Here the available data on the function of CD5 and its involvement in the regulation of immune responses in health and disease are reviewed, as well as the evidence for and future challenges in developing therapeutic strategies aimed at targeting CD5 for autoimmune diseases, cancer, and infections.

Citations

May 14, 2016·International Journal of Cancer. Journal International Du Cancer·Miriam PotronyFrancisco Lozano
May 16, 2017·European Journal of Immunology·Marcos VasquezPedro Berraondo
Sep 1, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Fabien PitoisetMichelle Rosenzwajg
Apr 28, 2018·International Journal of Molecular Sciences·Claudia M Tellez FreitasK Scott Weber
Jan 4, 2018·Oncotarget·Inês T SimõesFrancisco Lozano
Oct 14, 2020·Antimicrobial Agents and Chemotherapy·María Velasco-de AndrésFrancisco Lozano
May 3, 2019·Oncology Reviews·Kaveh JasebNajmaldin Saki
Jun 17, 2021·Immunology and Cell Biology·Josefine WadenpohlMarc Jacobsen

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