PMID: 7523048Jul 1, 1994Paper

CD5+ B-cells at the onset of type I diabetes and in the prediabetic period

Diabetes Care
R A SmerdonD Vergani

Abstract

B-cells expressing CD5 are associated with the production of autoantibodies and are present at increased levels in several autoimmune diseases. The aim of this study was to investigate the relationship of these cells to the development of type I diabetes and the presence of organ and non-organ-specific autoantibodies. We measured percentage levels of CD5+ B-cells in patients with recent-onset (n = 34) and long-standing (n = 21) type I diabetes and in a cohort of 18 identical twins of patients with type I diabetes studied prospectively, 8 of whom became diabetic (prediabetic twins) during the study; the rest remained nondiabetic after at least 7 years and are now unlikely to develop the disease. Forty-seven healthy individuals were studied as control subjects. Percentage levels of total B-cells (CD20+) and the proportion expressing CD5 were increased in patients with recent-onset (P < 0.001 for both) but not long-standing type I diabetes compared with control subjects. Percentage levels of CD20+ B-cells were increased in prediabetic twins throughout the prediabetic period (P < 0.05), and there was an increased proportion of CD5-expressing B-cells that failed to reach statistical significance (P = 0.08). Percentage levels of CD20...Continue Reading

Citations

Apr 8, 1999·Clinical and Experimental Immunology·T GrünewaldF Buttgereit
Feb 1, 1997·Endocrine Research·A AfeltraA Paggi
Aug 6, 1999·Autoimmunity·J GyarmatiG Soltész
Apr 26, 2017·Frontiers in Immunology·Ankit SaxenaAbdel Rahim A Hamad

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