PMID: 9187540Feb 1, 1997Paper

CD5 B cells in autoimmune and non immune-mediated thyroid dysfunctions

Endocrine Research
A AfeltraA Paggi

Abstract

In a previous study we demonstrated a significant increase of CD5+ B subset in patients with Graves' disease (GD) compared with normal controls. The aim of this study was to compare the percentage of CD5+ B and CD5- B cells in GD with that in different forms of autoimmune and non immune-mediated thyroid diseases. Seventy-two patients were studied: 28 patients with GD, 20 with silent thyroiditis (ST), 12 with Hashimoto's disease (HD), and 12 subjects affected by hyperthyroidism due to toxic adenoma (TA). Eleven out of 28 patients with GD were also evaluated after six months of methimazole treatment. The study was performed by cytometric analysis. In GD the percentage and the absolute number of CD5+ B cells were significantly increased compared with normal controls (42.5 +/- 18.2% versus 19 +/- 6.3%, p < 0.0001; 142 +/- 153.3/cmm versus 46.9 +/- 22/cmm, p < 0.003, respectively. CD5+ B cells tended to normalise after six months of treatment. In ST the percentage of CD5+ B cells was increased (28.6 +/- 10.2%); conversely the absolute number was in the normal range. Patients affected by HD did not show any significant modification in B cells and their subsets in comparison with controls. In TA, CD5+ B were 7.6 /- 4.4% and 14.3 /- 10...Continue Reading

References

Aug 1, 1990·Clinical Immunology and Immunopathology·E S Raveche
Nov 1, 1989·Immunology Today·P Casali, A L Notkins
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·R N Maini, C P Zyberk
May 1, 1988·Arthritis and Rheumatism·M DauphinéeN Talal
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·B A BaethgeR E Wolf
Feb 1, 1987·Journal of Dental Research·N Talal
Jan 1, 1986·Annales De L'Institut Pasteur. Immunology·J F Kearney, M Vakil
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M KatakuraM Kanai
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E G EnglemanR Levy
Jan 1, 1995·Autoimmunity·S AragaK Takahashi
Mar 1, 1993·Endocrine Research·A AfeltraL Bonomo

❮ Previous
Next ❯

Citations

Jul 10, 2001·Thyroid : Official Journal of the American Thyroid Association·C SegundoJ A Brieva
Jan 23, 1999·Current Opinion in Hematology·P M LydyardP Y Youinou
Sep 17, 1998·Endocrine Research·A AfeltraA Amoroso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.