CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte.

Autoimmunity Reviews
Rizgar A MageedPierre Youinou

Abstract

CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.

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Citations

Mar 19, 2015·Viruses·Christelle Le DantecYves Renaudineau
Oct 22, 2014·Arthritis & Rheumatology·Sebastian UnizonyJohn H Stone
Jun 22, 2014·International Journal of Occupational Medicine and Environmental Health·Piotr KłucińskiGayane Martirosian
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Sep 15, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Diana AhmetspahicJudith Alferink
Jun 12, 2019·Clinical Reviews in Allergy & Immunology·Alexis GrasseauSophie Hillion
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May 3, 2019·Oncology Reviews·Kaveh JasebNajmaldin Saki
Nov 18, 2020·Molecular Therapy. Methods & Clinical Development·Narjes Saheb Sharif-AskariRabih Halwani

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