CD5+ true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation: case report and review of the literature

Leukemia & Lymphoma
H L EvansC H Dunphy

Abstract

Lymphoplasmacytic lymphoma (LPL) and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL)are distinct clinicopathologic entities. Although some cases of SLL/CLL may show plasmacytic differentiation and be associated with monoclonal immunoglobulin in serum, such cases appear to be very rare, and if plasma cell differentiation were marked, differentiation of SLL/CLL from LPL could be difficult. We report a rare case of true CD5-positive small lymphocytic lymphoma/chronic lymphocytic leukemia with unequivocal plasmacytic differentiation. This case also showed an abnormality of chromosome 1p36 not previously described in small lymphocytic lymphoma/chronic lymphocytic leukemia.

Citations

Jul 25, 2006·The American Journal of Surgical Pathology·Ken H YoungDennis D Weisenburger
Jan 26, 2011·The American Journal of Surgical Pathology·Carlo ViscoKen H Young
Mar 15, 2013·Leukemia & Lymphoma·Panagiotis BaliakasTheodora Papadaki
Jan 11, 2007·American Journal of Clinical Pathology·Adam C SeegmillerNitin J Karandikar
Oct 11, 2016·Indian Journal of Pathology & Microbiology·Yi XieAnand S Lagoo
Feb 8, 2007·Cancer Genetics and Cytogenetics·K F Wong
Jan 4, 2013·The American Journal of Surgical Pathology·Daniel MartinezAntonio Martinez
Jan 27, 2019·Virchows Archiv : an International Journal of Pathology·Christiane Stuhlmann-LaeiszChristoph Röcken

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