CD56 (NCAM)-positive malignant lymphoma

Leukemia & Lymphoma
K F WongC S Ng

Abstract

CD56, a natural killer cell marker reactive with the neuronal-cell adhesion molecule (NCAM), identifies a group of lymphomas with distinctive clinicopathologic features. The disease affects mostly middle-aged adults who often present with fever, skin rash and hepatosplenomegaly in the absence of peripheral lymphadenopathy. Extranodal involvement is common, particularly the skin, aerodigestive tract and central nervous system. Histologically, an angiocentric and angiodestructive pattern of infiltrate is often seen, but the cytological spectrum of the lymphoma cells is very broad. Cytoplasmic granules, however, are frequently found when Giemsa-stained cytologic preparations are examined. Immunologically, CD56-positive lymphomas can be sub-classified into CD3-positive (T-cell) and CD3-negative (probably true natural killer cell) subtypes. T-cell receptor gene rearrangement can be demonstrated in the former cases, but not in the latter. Clinically, CD56-positive lymphomas are aggressive neoplasms.

References

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Citations

Jul 1, 1995·Cancer Genetics and Cytogenetics·K F WongK Y Lai
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Jul 24, 2003·Seminars in Hematology·Michael M C CheungKit-Fai Wong
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Armita BahramiJae Y Ro

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