CD57+ T lymphocytes are derived from CD57- precursors by differentiation occurring in late immune responses

European Journal of Immunology
A D d'AngeacM Salmon

Abstract

CD3+ T cells expressing the 110-kDa CD57 antigen are found in survivors of renal, cardiac and bone marrow transplants, in patients with acquired immune deficiency syndrome and in patients with rheumatoid arthritis. They are also present in normal individuals and expand upon ageing. They do not grow in culture and their role in the immune response is poorly understood. The expression of the various isoforms of the leukocyte common antigen (CD45) identifies a spectrum of differentiation in CD4+ and CD8+ T cells ranging from naive (CD45RA+CD45RBbrightCD45RO-) through early primed cells (CD45RA-RBbrightROdull) to highly differentiated memory cells which are CD45RA-RBdullRObright. CD45 isoforms expressed by CD57+ T cells showed distinct differences between CD4+ and CD8+ populations, but in each case indicated an advanced state of differentiation. The expression of T cell receptor V beta families was highly variable between individuals, but both CD57+ and CD57- cells show a full range of the specificities tested. V beta expression was more closely related within either the CD4+ or the CD8+ subsets, irrespective of CD57 expression, than between these subsets, suggesting a relationship between CD57+ and CD57- cells within the same T ce...Continue Reading

References

Aug 1, 1992·Arthritis and Rheumatism·C M BurnsN J Zvaifler
Oct 1, 1991·European Journal of Immunology·A N AkbarG Janossy
Mar 1, 1985·The Biochemical Journal·M J Clemens, M A McNurlan
May 1, 1993·Arthritis and Rheumatism·N MatthewsM Salmon
Apr 1, 1985·Immunology Today·G Trinchieri, B Perussia

❮ Previous
Next ❯

Citations

Feb 13, 2002·Arthritis and Rheumatism·Takeshi MaedaYukihide Iwamoto
Feb 1, 1997·Arthritis and Rheumatism·E C WangL K Borysiewicz
Sep 1, 1996·Journal of Clinical Immunology·C G MullighanK I Welsh
Mar 15, 2000·Transplantation Proceedings·C HebibB Charpentier
Oct 24, 2002·Human Immunology·Urban J ScheuringArgyrios N Theofilopoulos
Apr 2, 2003·Blood Cells, Molecules & Diseases·Margarida LimaBenvindo Justiça
Jul 17, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Peter LamprechtAntje Muller
Mar 21, 1998·British Journal of Haematology·M A FrassanitoF Dammacco
May 5, 1998·Clinical and Experimental Immunology·J MerinoM L Subirá
Mar 8, 2002·Clinical and Experimental Immunology·S J C GolbyJ Spencer
Sep 1, 1999·Immunology·A W RowbottomE G Corley
Jan 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Weiwei CaoRoger Detels
May 4, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A B RickinsonN E Annels
May 4, 2007·The British Journal of Ophthalmology·Miguel Pedroza-SeresMaria Carmen Jimenez-Martinez
Oct 7, 2004·Cytometry. Part B, Clinical Cytometry·Ingmar A F M HeijnenUNKNOWN European Working Group on Clinical Cell Analysis
Nov 18, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Karen L WoodHomer L Twigg
Oct 7, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Joanna Przeździecka-DołykMarta Misiuk-Hojło
Jul 14, 2012·La Presse médicale·Paul CoppoKaiss Lassoued
Apr 20, 2001·International Endodontic Journal·P R MoreiraR S Gomez
Jun 1, 2018·The Journal of Clinical Investigation·Lorraine YeoMark Peakman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.