CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair

Cell Death & Disease
Yuzhen ZhouWeiguo Hu

Abstract

Radiation therapy is an important treatment modality for esophageal cancer. However, acquisition of radioresistance ultimately results in esophageal cancer relapse. CD59, a membrane-bound complement regulatory protein, can transduce signals via a Src kinase in the lipid raft, thus playing a complement-independent role. However, the effect of CD59 on the esophageal cancer response to ionizing radiation remains unclear. In this study, we found that the expression level of CD59 was positively correlated with the radioresistance of esophageal cancer cell lines and clinical specimens. High CD59 expression indicated poor overall survival (OS) and disease-free survival (DFS) in esophageal squamous cell carcinoma (ESCC) patients who received radiotherapy. Genetic alteration of CD59 expression modulated the radiosensitivity of esophageal cancer cells to ionizing radiation. CD59 deficiency exacerbated DNA damage, hindered cell proliferation, and induced G2/M cell cycle arrest and cellular senescence, leading to an impaired DNA damage repair ability. In addition, CD59 deficiency almost completely reduced the phosphorylation of Src at Y416 despite ionizing radiation. A Src inhibitor saracatinib sensitized esophageal cancer cells to irradia...Continue Reading

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Citations

Jan 29, 2020·Cell Biochemistry and Function·Mahmoud Abdel-LatifBasant M Morsy
Oct 16, 2019·Oncology Letters·Fei YaoQingming Wu
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Hongtao ZhuKai Shu
Jun 24, 2021·Molecular Cancer Therapeutics·Hong Shik YunKevin Camphausen
Jan 15, 2022·Medical & Biological Engineering & Computing·Xiongshi DengLei Wang
Feb 4, 2022·Journal of Cancer Research and Clinical Oncology·Irina LarionovaEvgeny Denisov

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Methods Mentioned

BETA
xenograft
irradiating

Software Mentioned

SPSS

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