CD59a deficiency exacerbates ischemia-reperfusion injury in mice.

The American Journal of Pathology
Daniel TurnbergH Terence Cook

Abstract

The terminal complement components C5a and the membrane attack complex are involved in the pathogenesis of ischemia-reperfusion injury in many organs. CD59 is the major regulator of membrane attack complex formation. Mice deficient in the Cd59a gene (mCd59a-/-) were used to investigate the role of CD59 in renal ischemia-reperfusion injury. Unilateral ischemia-reperfusion injury was induced by clamping the left renal pedicle for 30 minutes under general anesthetic. Mice were studied at 72 hours and 2 weeks after ischemia-reperfusion injury. mCd59a-/- mice developed significantly greater tubular injury (P = 0.01), tubulointerstitial apoptosis (P = 0.02), and neutrophil influx (P = 0.04) than controls at 72 hours after ischemia-reperfusion. Two weeks after ischemia-reperfusion, mCd59a-/- mice exhibited more severe tubular damage predominantly in a corticomedullary distribution than controls (P = 0.02). Quantification of interstitial leukocytes revealed significantly greater numbers of infiltrating lymphocytes (but not macrophages) in mCd59a-/- mice than controls (P = 0.04) at 2 weeks. At both time points, significantly more C9 (as a marker of membrane attack complex) deposition occurred in a peritubular distribution in mCd59a-/- m...Continue Reading

References

Mar 1, 1978·The Journal of Clinical Investigation·P R MarokoS L Hale
Feb 1, 1992·Cardiovascular Research·D J Hearse, R Bolli
Jan 1, 1991·International Archives of Allergy and Applied Immunology·M SchönermarkG M Hänsch
Apr 1, 1990·Kidney International·I TorbohmG M Hänsch
Jan 1, 1988·International Archives of Allergy and Applied Immunology·G M HänschB Sterzel
Apr 1, 1971·The Journal of Experimental Medicine·J H Hill, P A Ward
Jul 1, 1994·Kidney International·S MatsuoB P Morgan
Feb 15, 1996·The Journal of Clinical Investigation·K J KellyJ V Bonventre
May 1, 1997·Kidney International·H RabbH R Brady
Mar 17, 1998·Journal of Molecular and Cellular Cardiology·K S KilgoreB R Lucchesi
Aug 5, 1998·Kidney International·A V CybulskyA J McTavish
Nov 7, 1999·The American Journal of Pathology·A V CybulskyA J McTavish
Dec 22, 1999·The American Journal of Physiology·C KyriakidesH B Hechtman
May 17, 2000·The Journal of Clinical Investigation·W ZhouS H Sacks
Mar 7, 2001·Kidney International·W G CouserS J Shankland
Jul 27, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·X QinJ A Halperin
Mar 1, 2002·European Journal of Immunology·Alma J NautaAnja Roos
Jun 19, 2002·Journal of Applied Physiology·Hui ZhaoGregory L Stahl
Dec 11, 2002·Kidney International·Thiruma V ArumugamStephen M Taylor
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua M ThurmanV Michael Holers
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bart de VriesWim A Buurman
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Daniel TurnbergH Terence Cook
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koei YamadaWen-Chao Song

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Citations

Apr 14, 2012·The Journal of Biological Chemistry·Alexander E AleshinRobert C Liddington
Jan 31, 2006·The Journal of Clinical Investigation·Joshua M ThurmanV Michael Holers
Mar 6, 2010·Journal of Neuroinflammation·Denise HarhausenGeorge Trendelenburg
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Qi PengWuding Zhou
Apr 26, 2013·Kidney International·Takehiko Wada, Masaomi Nangaku
May 15, 2009·Scandinavian Journal of Immunology·E D PedersenT E Mollnes
Sep 6, 2008·The American Journal of Pathology·Xiufen ZhengWei-Ping Min
Dec 13, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·David D Kim, Wen-Chao Song
Jun 1, 2013·Seminars in Immunology·Ke Li, Wuding Zhou
May 18, 2016·Seminars in Immunology·R M MonteroR A Smith
Jun 7, 2014·Current Opinion in Organ Transplantation·Julia MenkeJens Lutz
May 26, 2012·Nature Reviews. Immunology·Steven H Sacks, Wuding Zhou
May 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Tao LinSteven H Sacks
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nalini S BoraPuran S Bora
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel TurnbergH Terence Cook
Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kees FluiterValeria Ramaglia
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Purushottam JhaNalini S Bora

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