CD5L, Macrophage Apoptosis Inhibitor, Was Identified in Epicardial Fat-Secretome and Regulated by Isoproterenol From Patients With Heart Failure

Frontiers in Physiology
Rosa M Agra-BermejoSonia Eiras

Abstract

Neurohormonal dysfunction, which can regulate epicardial fat activity, is one of the main promoters of atrial fibrillation (AF) in patients with heart failure (HF). Our aim was to study the epicardial fat mediators for AF in patients with HF and its catecholaminergic regulation. We have included 29 patients with HF who underwent cardiac surgery and were followed up for 5 years. Released proteins by epicardial adipose tissue (EAT) after isoproterenol treatment were identified by nano-high-performance liquid chromatography (HPLC) and triple time-of-flight (TOF) analysis. Common and differential identified proteins in groups of patients with AF before and after surgery were determined by the FunRich tool. Plasma and epicardial fat biopsy proteins were quantified by western blot. Our results identified 17 common released proteins by EAT, after isoproterenol treatment, from HF patients who suffered AF or developed new-onset AF during follow-up. Mostly, they were involved on inflammatory response and extracellular matrix. One of them was CD5L, a macrophage apoptosis inhibitor. Its secretion by isoproterenol treatment was validated on western blot. The CD5L levels on epicardial fat were also higher in the group of male patients who pr...Continue Reading

References

Mar 1, 1996·Analytical Chemistry·A ShevchenkoM Mann
Aug 2, 2002·The New England Journal of Medicine·Satish KenchaiahRamachandran S Vasan
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Jun 9, 2006·International Journal of Cardiology·Gianluca IacobellisArya M Sharma
Jul 12, 2008·Journal of the American College of Cardiology·Eleftherios M KallergisPanos E Vardas
Aug 15, 2008·Journal of Proteome Research·Wilfred H TangSean L Seymour
Feb 24, 2009·The American Journal of Cardiology·Giovanni FilardoPaul A Grayburn
Oct 31, 2009·Journal of the American College of Cardiology·Filippos TriposkiadisJaved Butler
Dec 5, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Antony J Workman
Jun 19, 2010·Circulation. Arrhythmia and Electrophysiology·George ThanassoulisEmelia J Benjamin
Jun 7, 2015·Journal of Leukocyte Biology·Lucía SanjurjoMaria-Rosa Sarrias
Mar 26, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Masato FuruhashiTetsuji Miura
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Dec 31, 2016·Journal of Cardiovascular Translational Research·Sonia EirasJosé R González-Juanatey
Mar 4, 2017·Journal of Cardiovascular Electrophysiology·Akira FukuiNaohiko Takahashi
Jul 1, 2017·Journal of Geriatric Cardiology : JGC·Pyotr G Platonov
Feb 13, 2018·JACC. Clinical Electrophysiology·Ethan J AndersonAlan P Kypson
Apr 18, 2018·European Journal of Heart Failure·Miguel M Fernandes-SilvaScott D Solomon

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Citations

May 19, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Marinela Couselo-SeijasSonia Eiras

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Methods Mentioned

BETA
biopsies
coronary artery bypass
electrophoresis
reverse-phase chromatography
chips

Software Mentioned

Progroup
Analyst TF
Protein Pilot TM
SCIEX
Paragon
FunRich
Quantity One

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