PMID: 9436462Jun 1, 1997Paper

CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes

Immunology Letters
Nora G SingerB J Nickoloff

Abstract

The CD6 glycoprotein is expressed by T lymphocytes and is hypothesized to interact with one or more ligands expressed on antigen presenting cells (APCs). We show that CD6 mediates binding of the transformed CD4+ T cell line Hut 78 to gamma-interferon activated keratinocytes (KCs). A recombinant CD6-Ig fusion protein has been reported to bind to a CD6 ligand ALCAM, but this is the first demonstration that cell-cell adhesion of human T lymphocytes can be CD6 dependent. The known CD6 ligand ALCAM (CD166) is expressed on cultured KCs but does not appear to mediate KC-Hut 78 binding, suggesting the existence of additional CD6 ligands expressed on KCs. In functional studies using autologous KCs as APCs for tetanus toxoid specific T cell clones, KCs +/- gamma-interferon are unable to stimulate autologous T cells with recall antigen. Therefore interaction of T cell CD6 with CD6 ligands on KCs does not provide sufficient co-stimulation of primed T cells to support responses to nominal antigen.

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Citations

Apr 10, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Mafalda Pinto, Alexandre M Carmo
Jun 5, 2003·Developmental Biology·Kazuyuki OhboToshio Suda
Apr 12, 2002·Veterinary Immunology and Immunopathology·Aric N RogersCynthia L Baldwin
Feb 19, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Solomon F Ofori-Acquah, Judy A King
Jun 1, 2002·International Immunology·Nora G SingerR Michael Sramkoski
Mar 25, 2018·Cellular & Molecular Immunology·David A Fox
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Gospel Enyindah-AsonyeFeng Lin
May 17, 2007·European Journal of Immunology·Antony P B BlackGraham S Ogg
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P J Polverini, J E Nör
Apr 21, 2020·Arthritis & Rheumatology·Yan LiFeng Lin
Oct 17, 2017·Frontiers in Immunology·Marta Consuegra-FernándezFrancisco Lozano
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammad K SaifullahNora G Singer
Feb 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yan LiFeng Lin
Jan 9, 2019·Frontiers in Immunology·Carine M GonçalvesAlexandre M Carmo
Aug 22, 2017·The American Journal of Pathology·Ann-Helen WillrodtCornelia Halin

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